157997-38-1 Usage
Description
2H-Imidazole-2-selone, 1,3-dihydro-1-methylis a selenium-containing compound that is derived from 1-Methylimidazole (M312980), a metabolite of 1-Methyl-2-thioimidazole (methimazole). 2H-Imidazole-2-selone, 1,3-dihydro-1-methylexhibits properties that make it a potential candidate for various applications, particularly in the medical field.
Uses
Used in Pharmaceutical Industry:
2H-Imidazole-2-selone, 1,3-dihydro-1-methylis used as an inhibitor for lactoperoxidase (LPO) for the treatment of hyperthyroidism. Its ability to inhibit LPO makes it a valuable compound in managing the overproduction of thyroid hormones, which is a characteristic of hyperthyroidism.
Additionally, 2H-Imidazole-2-selone, 1,3-dihydro-1-methylis used as an inhibitor of bone resorption. This application is significant in the field of orthopedics and endocrinology, as it can help in the treatment and management of conditions related to bone loss, such as osteoporosis.
Check Digit Verification of cas no
The CAS Registry Mumber 157997-38-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,9,9 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 157997-38:
(8*1)+(7*5)+(6*7)+(5*9)+(4*9)+(3*7)+(2*3)+(1*8)=201
201 % 10 = 1
So 157997-38-1 is a valid CAS Registry Number.
157997-38-1Relevant articles and documents
A Direct Metalation Route to the Selenium Analogue of Methimazole
Guziec, Lynn James,Guziec, Frank S.
, p. 4691 - 4692 (1994)
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Interactions of antithyroid drugs and their analogues with halogens and their biological implications
Roy, Gouriprasanna,Bhabak, Krishna P.,Mugesh, Govindasamy
experimental part, p. 2279 - 2286 (2012/05/05)
The selenium analogue of antithyroid drug methimazole (MSeI) reacts with molecular bromine to produce two different types of novel complexes depending upon the molar ratio of MSeI to Br2 in the reaction medium. Dicationic diselenide complex wit
Synthesis and structural characterization of 1-mesityl-1,3-dihydro- imidazole-2-selone and bis(1-mesitylimidazol-2-yl)diselenide: Experimental evidence that the selone is more stable than the selenol tautomer
Landry, Victoria K.,Minoura, Mao,Pang, Keliang,Buccella, Daniela,Kelly, Bryte V.,Parkin, Gerard
, p. 12490 - 12497 (2007/10/03)
1-Mesityl-1,3-dihydro-imidazole-2-selone, (seimMes)H, may be obtained from 1-mesitylimidazole via (i) deprotonation with BunLi, (ii) treatment with elemental selenium, and (iii) addition of HCl(aq). Structural characterization of (se
