1581756-74-2

Upstream product

• 98-88-4 benzoyl chloride 
• 495-18-1 Benzohydroxamic acid 
• 5957-90-4 4-(2-pyridinyl)anisole 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 109-04-6 2-bromo-pyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2446-51-7 N-methoxybenzamide 

Relevant academic research and scientific papers

[Cp*RhIII]/Ionic Liquid as a Highly Efficient and Recyclable Catalytic Medium for C?H Amidation

A [Cp*RhIII]-catalyzed direct C?H amidation is carried out in ionic liquid. Both C(sp2)?H bonds of (hetero)arenes and alkenes and unactivated C(sp3)?H bonds can be easily amidated with high functional-group tolerance and excellent yields under these conditions. Notably, using [Cp*RhIII]/[BMIM]BF4 (BMIM=1-butyl-3-methylimidazolium) as the green and recyclable medium is environmentally benign, in light of characteristics such as the reusability of the expensive rhodium catalyst, avoidance of highly toxic organic solvents, and mild reaction conditions, as well as a short reaction time.

Ortho–C–H amidations enabled by a recyclable manganese-ionic liquid catalytic system

We described an environmentally benign, recyclable base metal catalyst system (MnBr(CO)5/[Hmim]OAc) for ortho–C–H amidation. The readily available dioxazolones was used as the amidation agents. A broad substrate scope and high functional group

Rh(III)-Catalyzed C-H Amidation of Arenes with N-Methoxyamide as an Amidating Reagent

The Rh(III)-catalyzed amidation of C(sp2)-H bonds has been reported by employing the N-methoxyamide as a novel amino source. An excellent level of functional group tolerance can be achieved when N-methoxyamide derivatives are used as the amidating reagents. Importantly, several known bioactive compounds such as Aminalon, Pregabalin, Gabapentin, and Probenecid can be transformed to effective amidating reagents, as a way to facilitate the development of new bioactive molecules.

Rhodium-Catalyzed C?H Activation Enabled by an Indium Metalloligand

Rhodium complexes with an indium metalloligand were successfully synthesized by utilizing a pyridine-tethered cyclopentadienyl ligand as a support for an In?Rh bond. The indium metalloligand dramatically changes the electronic and redox properties of the

Comparative Catalytic Activity of Group 9 [CpMIII] Complexes: Cobalt-Catalyzed C-H Amidation of Arenes with Dioxazolones as Amidating Reagents

A procedure for the [CpCoIII]-catalyzed direct C-H amidation of arenes with dioxazolone has been developed. This reaction proceeds under straightforward and mild conditions with a broad range of substrates, including anilides. A comparative study on the catalytic activity of Group 9 [{CpMCl2}2] complexes revealed the unique efficiency of the cobalt catalyst. Pick of the bunch: A variety of arenes, including anilides, underwent direct C-H amidation with dioxazolones in the presence of a cobalt catalyst with a Cp? ligand under mild and straightforward reaction conditions (see scheme; Piv=pivaloyl). A comparative study of Group 9 [CpMIII] complexes revealed the unique ability of the cobalt catalyst to promote this transformation efficiently.

Mechanistic Studies on the Rh(III)-Mediated Amido Transfer Process Leading to Robust C-H Amination with a New Type of Amidating Reagent

Mechanistic investigations on the CpRh(III)-catalyzed direct C-H amination reaction led us to reveal the new utility of 1,4,2-dioxazol-5-one and its derivatives as highly efficient amino sources. Stepwise analysis on the C-N bond-forming process showed th

Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl C-H Amidation: A Mild Protocol for the Modification of Purine Derivatives

A cationic cobalt(III)-catalyzed direct C-H amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions wit

Orthogonal reactivity of acyl azides in C-H activation: Dichotomy between C-C and C-N amidations based on catalyst systems

The dual reactivity of acyl azides was utilized successfully in C-H activation by the choice of catalyst systems: while selective C-C amidation was achieved under thermal Rh catalysis, a Ru catalyst was found to mediate direct C-N amidation also highly se