158177-75-4Relevant academic research and scientific papers
Towards a versatile synthesis of kainoids I: Introduction of the C-3 and C-4 substituents
Baldwin, Jack E.,Bamford, Samantha J.,Fryer, Andrew M.,Rudolph, Martin P. W.,Wood, Mark E.
, p. 5233 - 5254 (2007/10/03)
The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy-L-proline are described. An enamine alkylation was used to stereospecifically introduce the C-3 substituent, Grignard addition to a ketone or Pd(0) catalysed cross-coupling procedures adding C-4 aryl substituents for further manipulation. A number of versatile intermediates were generated.
A concise approach to kainoid analogues
Baldwin, Jack E.,Rudolph, Martin
, p. 6163 - 6166 (2007/10/02)
Highly neuroexcitatory kainoid analogues bearing an aryl substituent at C-4 were synthesised by a short and efficient route from trans-L-4-hydroxypyroline.
