1582741-08-9Relevant academic research and scientific papers
β-Hydroxy-γ-lactones as nucleophiles in the Nicholas reaction for the synthesis of oxepene rings. Enantioselective formal synthesis of (-)-isolaurepinnacin and (+)-rogioloxepane A
Rodriguez-Lopez, Julio,Ortega, Nuria,Martin, Victor S.,Martin, Tomas
, p. 3685 - 3688 (2014/04/03)
The enantioselective formal synthesis of (-)-isolaurepinnacin and (+)-rogioloxepane A has been achieved. The key steps are an intermolecular Nicholas reaction with a β-hydroxy-γ-lactone as the nucleophile, to form branched linear ethers, and an olefin ring-closing metathesis to obtain the oxepene core. This journal is the Partner Organisations 2014.
