15828-08-7

Basic information

• Product Name: N-tert-Butylnicotinamide
• Synonyms: N-tert-Butylnicotinamide
• CAS NO: 15828-08-7
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23096
• Mol File: 15828-08-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N-tert-Butylnicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butylnicotinamide(15828-08-7)
• EPA Substance Registry System: N-tert-Butylnicotinamide(15828-08-7)

Safety Data

• Hazardous Substances Data: 15828-08-7(Hazardous Substances Data)

Usage

General Description

N-tert-Butylnicotinamide, also known as tBNA, is a chemical compound that belongs to the class of nicotinamide derivatives. It is a derivative of nicotinamide, which is a form of vitamin B3. N-tert-Butylnicotinamide is commonly used as a corrosion inhibitor in various industries, such as the automotive and aerospace sectors, as well as in the formulation of lubricants and metalworking fluids. It provides good anti-corrosive properties and is effective at protecting metal surfaces from degradation. In addition, N-tert-Butylnicotinamide has also been studied for its potential pharmaceutical applications, particularly for its anti-inflammatory and antioxidant properties. Overall, N-tert-Butylnicotinamide is a versatile chemical compound with a range of industrial and potential medicinal applications.

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Relevant articles and documents

Homogeneous catalytic aminocarbonylation of nitrogen-containing iodo-heteroaromatics. Synthesis of N-substituted nicotinamide related compounds

Various primary and secondary amines, including amino acid methyl esters, were used as nucleophiles in palladium-catalysed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine. N-Substituted nicotinamides and 3-pyridyl-glyoxylamides (2-oxo-carboxamide type derivatives) of potential biological importance can be obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The latter examples can be obtained in synthetically acceptable yields by using elevated carbon monoxide pressure. On the contrary, N-alkyl/aryl-carboxamides were obtained exclusively in the whole pressure range by using 2-iodopyridine and iodopyrazine.

Amide derivative

A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1is hydogen atom, optionally substituted alkyl, etc.; R2and R3are independently optionally substituted alkyl, etc.; R4and R5are independently hydrogen atom or optionally substituted alkyl; R6is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.

Reaction of magnesiated bases on substituted pyridines: Deprotonation or 1,4-addition?

N-(tert-Butyl)pyridine-2-carboxamide (1), N-phenylpyridine-2-carboxamide (7) and 2,2-dimethyl-N-(2-pyridyl)-propanamide (18) are readily deprotonated at C3 with a stoichiometric amount of PriMgCl or Bu2Mg in THF under reflux. Subsequ