15832-30-1

Usage

Uses

Used in Pharmaceutical Industry:
Isoxazolo[5,4-d]pyrimidin-4(5H)-one, 3-phenylis used as a potential drug candidate or lead compound for the development of new pharmaceuticals due to its unique structure and properties. It may exhibit activity against various diseases or conditions, offering a promising avenue for further research and exploration.
Used in Chemical Synthesis:
Isoxazolo[5,4-d]pyrimidin-4(5H)-one, 3-phenylserves as a valuable building block for the synthesis of other biologically active molecules. Its unique structure allows for the creation of novel compounds with potential applications in various fields, including medicine, agriculture, and materials science.

Upstream product

• 15783-70-7 5-amino-3-phenylisoxazole-4-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 
• 14246-77-6 5-amino-3-phenylisoxazole-4-carbonitrile 
• 64-18-6 formic acid 
• 698-16-8 benzohydroximoyl chloride 
• 932-90-1 Benzaldoxime 
• 100-52-7 benzaldehyde 

Downstream Products

• 75-13-8 isocyanic acid 
• 74-90-8 hydrogen cyanide 
• 145355-48-2 phenyliminopropadienone 
• 124-38-9 carbon dioxide 
• 14246-67-4 4-hydrazino-3-phenyl-isoxazolo[5,4-d]pyrimidine 
• 1124248-28-7 ethyl (4-oxo-3-phenylisoxazolo[5,4-d]pyrimidin-5(4H)-yl)acetate 

Relevant academic research and scientific papers

Synthesis, antibacterial, and antifungal activities of new pyrimidinone derivatives

An efficient synthesis of new pyrrolopyrimidinones 3a-d and isoxazolopyrimidinones 4a-c from the respective aminocyanopyrroles 1a-d and aminocyanoisoxazoles 2a-c is presented. The synthesized compounds were screened for antimicrobial activity against a panel of bacteria and fungi. Compound 4c exhibits remarkable activity against a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi.

Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo[5,4–d]pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents

A library of new 3-phenylisoxazolo[5,4–d]pyrimidines (8–10) was designed based on a scaffold hybridization technique incorporating the important pharmacophoric features of 4-aminopyrimidine and phenyl isoxazole scaffold which is renowned for its BET inhib

Novel selective ido1 inhibitors with isoxazolo[5,4-d]pyrimidin-4(5h)-one scaffold

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. A focused library was prepared using a 6-or 7-step synthetic procedure to allow a systematic investigation of the structure-activity relationships of the described scaffold. Chemistry-driven modifications lead us to the discovery of our best-in-class inhibitors possessing p-trifluoromethyl (23), p-cyclohexyl (32), or p-methoxycarbonyl (20, 39) substituted aniline moieties with IC50 values in the low micromolar range. In addition to hIDO1, compounds were tested for their inhibition of indoleamine 2,3-dioxygenase 2 and tryptophan dioxygenase, and found to be selective for hIDO1. Our results thus demon-strate a successful study on IDO1-selective isoxazolo[5,4-d]pyrimidin-4(5H)-one inhibitors, defining promising chemical probes with a novel scaffold for further development of potent small-molecule immunomodulators.

Regioselective synthesis of substituted isoxazolo[5,4-d]pyrimidines

A convenient regioselective synthesis of new N- and O-substituted isoxazolo[5,4-d]pyrimidine derivatives is described.