15832-98-1

Usage

General Description

2-Aminophenyldiethylcarbinol, also known as N-(2-hydroxyethyl)-1-phenylenediamine, is a chemical compound used in the synthesis of various pharmaceuticals and organic products. It is a white crystalline solid that is soluble in alcohol and ether, and slightly soluble in water. It has a molecular formula of C12H17NO and a molecular weight of 191.27 g/mol. 2-Aminophenyldiethylcarbinol has been studied for its antioxidant and antimicrobial properties, and has potential applications in the fields of medicine, food preservation, and cosmetics. However, it is important to handle and use this chemical with care, as it can be hazardous if not properly managed.

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 925-90-6 ethylmagnesium bromide 
• 118-92-3 anthranilic acid 
• 25672-97-3 2-(aminomethyl)-benzoic acid 
• 1196-28-7 2'-Aminopropiophenon 
• 10467-10-4 ethylmagnesium iodide 
• 87-25-2 2-ethoxycarbonylaniline 

Downstream Products

• 906648-90-6 tert-butyl {3-[2-(1-ethyl-1-hydroxy-propyl)-phenylamino]-1,1-dimethyl-propyl}-carbamate 
• 328009-77-4 C₁₈H₂₀N₂O₄ 
• 19013-49-1 2-ethyl-3-methylindole 
• 20873-99-8 2-(1-ethylprop-1-enyl)phenylamine 

Relevant academic research and scientific papers

Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles

A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallography. With PISA, various indoles were synthesized via C-H amination of 2-alkenylanilines involving an aryl migration/intramolecular cyclization cascade with excellent regioselectivity in aqueous CH3CN. Notably, using this new method as the key step, not only two drug molecules, indometacin and zidometacin, but also another bioactive molecule, pravadoline, were synthesized.

Sunlight-Driven Forging of Amide/Ester Bonds from Three Independent Components: An Approach to Carbamates

A photoredox catalytic route to carbamates enabled by visible irradiation (or simply sunlight) has been developed. This process leads to a novel approach to the construction of heterocyclic rings wherein the amide or ester motifs of carbamates were assembled from three isolated components. Large-scale experiments were realized by employing continuous flow techniques, and reuse of photocatalyst demonstrated the green and sustainable aspects of this method.

ENANTIOMERICALLY PURE BETA AGONISTS, MANUFACTURING AND USE THEREOF

The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R1, R2, R3, m and Ym? may have the meanings given in the claims and specification, processes for preparing them an

PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to new pharmaceutical combinations which contain in addition to one or more, preferably one compound of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the cl

POWDER FORMULATIONS FOR INHALATION CONTAINING ENANTIOMERICALLY PURE BETA-AGONISTS

The present invention relates to powder formulations for inhalation containing enantiomerically pure compounds of general Formula (I) wherein the groups R1, R2 and R3 may have the meanings indicated in the claims and in th

Amides as precursors of imidoyl radicals in cyclisation reactions

Amides have been successfully used as precursors of imidoyl radicals for radical cyclisation. The amides have been converted to imidoyl selanides via reaction with phosgene to yield imidoyl chlorides followed by reaction with potassium phenylselanide. Imidoyl selanides were reacted with tributyltin hydride (Bu3SnH) as the radical mediator with triethylborane or AIBN as initiators to yield imidoyl radicals for cyclisation reactions. Imidoyl radicals have been cyclised onto alkenes to yield 2,3-substituted-indoles and -quinolines and also onto pyrroles and indoles to give bi- and tricyclic heteroarenes.

SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists

We previously disclosed that 6-aryl benzoxazin-2-ones were PR modulators. In a continuation of this work we examined the SAR of new 6-arylamino benzoxazinones and found the targets 1-25, with an extra amino linker between the pendent 6-aryl groups and ben

Studies of 4H-3,1-benzoxazines. 14. Structure and some properties of 2-[2-hydroxyphenyl(naphthyl)]-1,2-dihydro-4H-3,1-benzoxazines

It has been shown that the condensation of tertiary aminophenylcarbinols with 2-hydroxybenz(naphth)aldehydes gives the corresponding 1,2- dihydrobenzoxazines and their structural Schiff base isomers. The reaction of 2-[2-hydroxyphenyl(naphthyl)]-1,2-dihyd

NEW PHARMACEUTICALLY-ACTIVE COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, R2 and R3 may have the meanings specified in the claims and in the description, for preparing a pharmaceutical compositi

Acyliminium ion-olefin cyclization leading to isoindolo[2,1-a]quinoline derivatives

Isoindolo[2,1-a]quinolines 10, 11, 12 were synthesized from hydroxylactams 8 or 9 via an N-acyliminium ion-π-olefin nucleophile cyclization reaction.