25672-97-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 2-(aminomethyl)(9CI) serves as a precursor in the production of various pharmaceuticals. Its unique chemical structure allows for the synthesis of different drug molecules, contributing to the development of new medications.
Used in Dye and Perfume Industry:
Benzoic acid, 2-(aminomethyl)(9CI) is utilized as a starting material for the synthesis of dyes and perfumes, providing a foundation for the creation of a wide range of colorants and fragrances.
Used as a Food Preservative:
Benzoic acid, 2-(aminomethyl)(9CI) is employed as a food preservative due to its ability to inhibit the growth of bacteria and fungi, thereby extending the shelf life of various food products.
Used in Polymer and Resin Production:
Benzoic acid, 2-(aminomethyl)(9CI) is also used in the manufacturing of specific polymers and resins, where its chemical properties contribute to the formation of desired material characteristics.
Health Risks:
It is important to handle Benzoic acid, 2-(aminomethyl)(9CI) with caution due to its potential health risks. Prolonged exposure may cause irritation to the skin, eyes, and respiratory system, necessitating proper safety measures during its use and production.

Upstream product

• 89-51-0 Homophthalic acid 
• 53663-18-6 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoic acid 
• 87-41-2 2-benzofuran-1(3H)-one 
• 95-13-6 1-indene 
• 14736-50-6 o-(methoxycarbonylmethyl)benzoic acid 
• 480-91-1 oxisoindole 

Downstream Products

• 1243610-73-2 2-((2-ethoxy-3,4-dioxocyclobut-1-enylamino)methyl)benzoic acid 
• 10017-39-7 (2-benzylamino)carboxylic acid hydrochloride 
• 119-67-5 o-carboxybenzaldehyde 
• 61088-45-7 methyl 2-(aminomethyl)benzoate 
• 771574-07-3 2-Aminomethyl-benzoic acid ethyl ester 
• 219640-94-5 2-(((fluorenylmethoxcarbonyl)amino)methyl)benzoic acid 
• 15832-98-1 2-aminophenyldiethylcarbinol 

Relevant academic research and scientific papers

Structural optimization and structure–activity relationship of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as hDHODH inhibitors. The preliminary structure–activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 μM and 1.45 μM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors.

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).

Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds

We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis. With a little help: A Ritter-type intermolecular amination of benzylic C-H bonds with acetonitrile, co-catalyzed by CuII/FeIII is reported. A wide array of biologically interesting nitrogen containing heterocycles was prepared from 2-alkyl benzoic acids and heteroaromatic carboxylic acids under operationally simple conditions. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.

BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS

Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: (I) and pharmaceutical compositions comprising the prodrugs.

Rationally designed squaryldiamides - A novel class of sugar-nucleotide mimics?

Sugar-nucleotides such as GDP-mannose, GDP-fucose and UDP-glucose are important biomolecules with a central role in carbohydrate and glycoconjugate biosynthesis, metabolism and cell signalling. Analogues and mimics of naturally occurring sugar-nucleotides are sought after as chemical tools and inhibitor candidates for sugar-nucleotide-dependent enzymes including glycosyltransferases. Many sugar-nucleotides bind to their target glycosyltransferases via coordination of the diphosphate group to a divalent metal cofactor in the active site. The identification of uncharged, chemically stable surrogates for the diphosphate group, with the ability to coordinate to a divalent metal, is therefore an important design criteria for the development of sugar-nucleotide mimics. Here, we describe the rational design and synthesis of a novel class of sugar-nucleotide mimics based on a squaryldiamide scaffold, an uncharged phosphate isostere. We demonstrate by comprehensive NMR titration experiments that the new sugar-nucleotide mimics coordinate efficiently to Mg2+, and provide results from biological studies with a therapeutically relevant mannosyltransferase from Trypanosoma brucei. Our findings suggest that squaryldiamides are a promising template for the development of sugar-nucleotide mimics, and illustrate the considerable potential of the squarylamide group as a fragment for inhibitor design. The Royal Society of Chemistry 2010.