15833-07-5

Basic information

• Product Name: 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
• Synonyms: 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL;2-BroMo-1,3,5(10)-estratriene-3,17b-diol
• CAS NO: 15833-07-5
• Molecular Formula: C₁₈H₂₃BrO₂
• Molecular Weight: 351.27802
• Product Categories: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 15833-07-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 447.3°Cat760mmHg
• Flash Point: 224.3°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 8.71E-09mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: Amber Vial, Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Stability: Light Sensitive
• CAS DataBase Reference: 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL(15833-07-5)
• EPA Substance Registry System: 2-BROMOESTRADIOL,(13S,17S)-2-BROMO-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL(15833-07-5)

Safety Data

• Hazardous Substances Data: 15833-07-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C18H23BrO2/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-16(20)15(19)9-13(10)11/h8-9,11-12,14,17,20-21H,2-7H2,1H3

Upstream product

• 15856-39-0 Acetic acid (13S,17S)-3-acetoxy-2-bromo-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester 
• 50-28-2 estradiol 
• 15856-39-0 2-bromo-3,17β-estradiol diacetate 
• 32158-57-9 estra-1,3,5(10)-triene-3,17β-diol 3-methoxymethyl ether 
• 19590-55-7 2,4-dibromoestradiol 
• 50-28-2 estradiol 
• 113680-59-4 2-trimethylsilylestra-1,3,5(10)-triene-3,17β-diol 3,17-bis(methoxymethyl) ether 
• 113680-60-7 2-trimethylsilyl-1,3,5(10)-triene-3,17β-diol 3-methoxymethyl ether 
• 133586-87-5 2-phenylselenenylestradiol 
• 1474-52-8 17β-oestradiol diacetate 
• 113680-55-0 (8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene 

Downstream Products

• 50-28-2 estradiol 
• 362-07-2 2-Methoxyestradiol 
• 686721-46-0 2-bromo-3-benzyloxyestra-1,3,5(10)-trien-17β-ol 
• 26788-23-8 4-methoxy-17β-estradiol 
• 5150-62-9 Estradiol 3,17-bis-TMS ether 
• 1818-12-8 2-Methyl-oestradiol 

Relevant articles and documents

C-2 hydroxylation of 2-deuterioestrogen in the rat. Lack of "NIH" shift".

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Electrochemical A-ring bromination of estrogens

A-ring bromination of estrogens has been achieved by constant current electrolysis of the solutions of these substrates and Et4NBr in appropriate solvents. Thus, electrolysis consuming 2 F mol-1 charge gave mixtures of 2- and 4-estrogens (1:1.1-2.5; up to 97%), whereas 4 F mol -1 charge experiments yielded 2,4-dibromoestrogens as the sole products.

A novel, 2 step synthesis of 2 methoxyestradiol

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Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging. This journal is

Chemical synthesis of six novel 17β-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms

Our earlier studies have shown that over 20 nonpolar 17β-estradiol metabolite peaks were detected following incubations of radioactive 17β-estradiol with human liver microsomes or recombinant human cytochrome P450 isoforms in the presence of NADPH as a co