1818-12-8

Usage

Uses

Used in Oncology:
2-Methylestradiol is used as an antitumor agent for its potential to inhibit the growth and proliferation of cancer cells. It is particularly effective against various types of tumors and malignancies due to its ability to interfere with the cell cycle and induce apoptosis in cancerous cells.
Used in Pharmaceutical Industry:
2-Methylestradiol is used as a pharmaceutical agent for the development of cancer treatments. Its unique properties as a metabolite of estradiol make it a promising candidate for the creation of novel therapeutics that can target and eliminate cancer cells while minimizing side effects on healthy cells.

InChI:InChI=1/C19H26O2/c1-11-9-15-12(10-17(11)20)3-4-14-13(15)7-8-19(2)16(14)5-6-18(19)21/h9-10,13-14,16,18,20-21H,3-8H2,1-2H3/t13-,14+,16-,18-,19-/m0/s1

Upstream product

• 2626-12-2 3-hydroxy-2-methyl-estra-1,3,5⁽¹⁰⁾-trien-17-one 
• 7251-38-9 17β-hydroxy-2-methyl-androsta-1,4-dien-3-one 
• 1452-40-0 17β-hydroxy-2α-methyl-4-androsten-3-one 
• 15833-07-5 2-bromoestradiol 
• 50-28-2 estradiol 
• 53-16-7 Estrone 
• 96111-26-1 2-(N,N-dimethylamino)methylestrone 
• 6599-97-9 2-formylestradiol 

Downstream Products

• 122426-75-9 3-benzoyloxy-2-methyl-estra-1,3,5(10)-trien-17β-ol 
• 51209-86-0 3-benzoyloxy-2-methyl-estra-1,3,5(10)-trien-17-one 

Relevant academic research and scientific papers

Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging. This journal is

3,17-Disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: Synthesis, in vitro and in vivo anticancer activity

Estradiol-3,17-O,O-bis-sulfamates inhibit steroid sulfatase (STS), carbonic anhydrase (CA), and, when substituted at C-2, cancer cell proliferation and angiogenesis. C-2 Substitution and 17-sulfamate replacement of the estradiol-3,17-O,O-bis-sulfamates we

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site

In order to define the structural parameters associated with the antitubulin activity and cytotoxicity of 2-methoxyestradiol, a mammalian metabolite of estradiol, an array of analogs was synthesized and evaluated. The potencies of the new congeners as inh