15854-73-6Relevant articles and documents
Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle
Takale, Balaram S.,Thakore, Ruchita R.,Casotti, Gianluca,Li, Xaiohan,Gallou, Fabrice,Lipshutz, Bruce H.
supporting information, p. 4158 - 4163 (2021/02/01)
An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500–1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.
Sulfonamide compound and medical applications thereof
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Paragraph 0044; 0046; 0048, (2019/02/13)
The invention discloses a compound containing a sulfonamide structure, a preparation method thereof, and medical applications of the compound, and more specifically discloses the compound with a structure represented by formula I, and a pharmaceutically acceptable salt or a prodrug or a solvate thereof. The compound is used for tumor treatment through inhibiting ATP-citrate lyase.
Compounding method for acaricide bifenazate intermediate 3-nitro-4-methoxyphenyl
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Paragraph 0028-0049, (2019/02/10)
The invention relates to a compounding method for an acaricide bifenazate intermediate 3-nitro-4-methoxyphenyl and belongs to the field of pesticide preparation. The compounding method is characterized by acquiring 3-nitro-4-methoxyphenyl from the reaction of 4-halogenated-2-nitroanisole and benzene halide under the action of catalyst. The reaction process is as follows: 1) uniformly mixing 4-halogenated-2-nitroanisole, benzene halide, catalyst and solvent A under a shielding gas condition, rising temperature to 130-150 DEG C, controlling pressure to 7-12 barometric pressures, reacting for 20-35h and ending; 2) performing vacuum filtration on the system and removing solid insoluble substances, thereby acquiring a filtrate a; pouring the filtrate a into 3-5 times of water, adding a solventB for extracting, layering and then using a drying agent for drying an organic phase, and concentrating, thereby acquiring a solid; re-crystallizing the solid with a solvent C, thereby acquiring 3-nitro-4-methoxyphenyl. The compounding method has the advantages of few steps, higher yield and more convenient operation.