885-82-5

Basic information

• Product Name: 4-HYDROXY-3-NITROBIPHENYL
• Synonyms: 2-NITRO-4-PHENYLPHENOL;3-NITRO[1,1'-BIPHENYL]-4-OL;3-NITROBIPHENYL-4-OL;4-HYDROXY-3-NITROBIPHENYL;4-HYDROXY-3-NITRODIPHENYL;Nitrophenylphenol;4-HYDROXY-3-NITROBIP;2-Nitro-4-phenylphenol 3-Nitrobiphenyl-4-ol
• CAS NO: 885-82-5
• Molecular Formula: C₁₂H₉NO₃
• Molecular Weight: 215.2
• EINECS: 212-946-3
• Product Categories: Biphenyl derivatives
• Mol File: 885-82-5.mol
• Article Data: 34

Chemical Properties

• Melting Point: 69-70°C
• Boiling Point: 338.5°C at 760 mmHg
• Flash Point: 145.1°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 4.98E-05mmHg at 25°C
• Refractive Index: 1.637
• PKA: 6.97±0.14(Predicted)
• Water Solubility: Insoluble in water
• BRN: 2331623
• CAS DataBase Reference: 4-HYDROXY-3-NITROBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-NITROBIPHENYL(885-82-5)
• EPA Substance Registry System: 4-HYDROXY-3-NITROBIPHENYL(885-82-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 885-82-5(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-3-NITROBIPHENYL is a chemical compound that consists of a biphenyl molecule with a hydroxyl group and a nitro group attached to it. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various organic compounds. This chemical is known to be a potential mutagen and is considered as a group 2B carcinogen by the International Agency for Research on Cancer. It is also known to be harmful if swallowed, inhaled, or absorbed through the skin. Due to its potential health hazards, proper precautions should be taken when handling 4-HYDROXY-3-NITROBIPHENYL in laboratory or industrial settings.

InChI:InChI=1/C12H9NO3/c14-12-7-6-10(8-11(12)13(15)16)9-4-2-1-3-5-9/h1-8,14H

Upstream product

• 28355-52-4 2-([1,1′-biphenyl]-4-yloxy)pyridine 
• 7693-52-9 4-bromo-2-nitrophenol 
• 98-80-6 phenylboronic acid 
• 1252036-52-4 4-hydroxy-3-nitrobenzenediazonium tetrafluoroborate 
• 92-69-3 4-Phenylphenol 
• 7722-84-1 dihydrogen peroxide 
• 64-19-7 acetic acid 
• 92-52-4 biphenyl 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 71-43-2 benzene 

Downstream Products

• 1134-36-7 2-amino-4-phenylphenol 
• 15854-73-6 3-nitro-4-methoxybiphenyl 
• 65407-95-6 2,5-diphenylbenzo[d]oxazole 
• 313527-64-9 4-(5-phenyl-benzoxazol-2-yl)-aniline 
• 139516-51-1 2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-6-phenyl-4H-benzo[1,4]oxazin-3-one 
• 139516-02-2 methyl 5-<4-(4-fluorophenyl)-1-piperazinyl>-2-(2-nitro-4-phenylphenoxy)valerate 
• 187461-69-4 Adamantan-1-yl-propynoic acid 4'-tert-butyl-3-nitro-biphenyl-4-yl ester 
• 149877-41-8 bifenazate 
• 39811-17-1 5-phenyl-O-anisidine 
• 869790-57-8 5-phenyl-2-(2-bromobenzyloxy)aniline 
• 92-05-7 3,4-dihydroxybiphenyl 

Relevant articles and documents

Nitration method for aryl phenol or aryl ether derivative

The invention relates to a nitration method for an aryl phenol or aryl ether derivative. The method comprises the steps of stirring an aryl phenol or aryl ether compound, nitrate, trimethylchlorosilane (TMSCl) and a copper salt in an acetonitrile solution in air at room temperature, simultaneously, monitoring extent of reaction through a TLC dot plate, removing a solvent from a mixture by a rotaryevaporator after a substrate is consumed completely, and carrying out purification through a silica-gel column, thereby obtaining a nitroolefin derivative. Meanwhile, the selective mono-nitration orbis-nitration of the substrate can be achieved through controlling equivalent weight of the nitrate. Compared with the prior art, the nitration method disclosed by the invention has the advantages that the consumption of strong-acid substances is avoided, the reaction conditions are mild, the yield is high, the applicable range of the substrate is wide, reaction activity is free of obvious attenuation after an amplified reaction, and an excellent yield is still obtained, so that the method has an obvious industrial application value.

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

A ortho-nitro phenol and its derivative synthesis method (by machine translation)

The invention relates to a method for the synthesis of organic compounds, in the existing technology of O-nitrophenol strong acid used in the synthesis process of the serious problem of environmental pollution and the synthesis step longer more complicated problem, the invention provides a ortho-nitro phenol and synthetic method of derivative thereof, proceeding by the phenol compound, synthesis of 2 - (phenoxy) pyridine, the obtained product, catalyst, tert-butyl nitrite, organic solvent and adding sealing in the pressure containers, in oil bath heating 50 - 100 °C, reaction 10 - 30 hours, to obtain 2 - (2 - nitrobenzene) ethoxy pyridine; re-processing by the ortho-nitro phenol and its derivatives; the method is simple, high-efficiency. (by machine translation)