39811-17-1

Basic information

• Product Name: 5-PHENYL-O-ANISIDINE
• Synonyms: TIMTEC-BB SBB000386;2-METHOXY-5-PHENYLANILINE;2-AMINO-4-PHENYLANISOLE;5-PHENYL-O-ANISIDINE;3-AMINO-4-METHOXYBIPHENYL;AURORA KA-7731;[1,1'-Biphenyl]-3-amine, 4-methoxy-;3-AMINO-4-METHOXYBIPHENYL 97+%
• CAS NO: 39811-17-1
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• EINECS: 254-639-7
• Mol File: 39811-17-1.mol

Chemical Properties

• Melting Point: 82-83 °C(lit.)
• Boiling Point: 336.78°C (rough estimate)
• Flash Point: 186.3 °C
• Appearance: brown coarse powder
• Density: 1.0671 (rough estimate)
• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: slightly sol. in Methanol
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: 5-PHENYL-O-ANISIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-O-ANISIDINE(39811-17-1)
• EPA Substance Registry System: 5-PHENYL-O-ANISIDINE(39811-17-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 39811-17-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Phenyl-o-anisidine is used as a key intermediate in the synthesis of various pharmaceutical compounds, specifically in the creation of 2,4-diamino-5-methyl-6-substituted-pyrido[2,3-d]pyrimidines. These compounds have potential applications in the development of new drugs and therapies.
Used in Chemical Research:
As a promising monomer for polyanilines studies, 5-Phenyl-o-anisidine is used in the field of chemical research to explore its properties and potential applications in the development of new materials and compounds.
Used in Material Science:
5-Phenyl-o-anisidine's unique chemical properties make it a valuable component in the field of material science, where it can be utilized in the development of new polymers and other advanced materials with specific properties and applications.

InChI:InChI=1/C13H19NO/c1-15-13-8-7-11(9-12(13)14)10-5-3-2-4-6-10/h7-10H,2-6,14H2,1H3

Upstream product

• 21524-23-2 3-Phenylazo-biphenyl-4-ol 
• 92-69-3 4-Phenylphenol 
• 33696-00-3 4-bromo-1-methoxy-2-nitrobenzene 
• 7693-52-9 4-bromo-2-nitrophenol 
• 92-04-6 2-chloro-4-phenylphenol 
• 3645-61-2 sodium 4-phenylphenoxide 
• 613-37-6 4-methoxylbiphenyl 
• 27701-66-2 4-bromo-3-nitrobiphenyl 
• 885-82-5 4-phenyl-2-nitrophenol 
• 15854-73-6 3-nitro-4-methoxybiphenyl 
• 21424-83-9 3-chloro-4-methoxy-1,1'-biphenyl 
• 7664-41-7 ammonia 
• 77422-75-4 C₂₀H₁₉N₃OS 
• 39811-16-0 (4-Methoxy-biphenyl-3-yl)-phenyl-diazen 

Downstream Products

• 196616-48-5 7-Methoxy-3-methyl-4-phenyl-1H-indole-2-carboxylic acid methyl ester 
• 817204-71-0 C₃₆H₃₄N₂O₆ 
• 796061-78-4 1H-imidazole-2-carboxylic acid (4-methoxy-biphenyl-3-yl)-amide 
• 1586025-53-7 6-methoxy-N-(4-methoxy-[1,1’-biphenyl]-3-yl)-2-(4-methoxyphenyl)benzo[b]thiophene-3-carboxamide 
• 692764-89-9 5-(4-methoxy[1,1'-biphenyl]-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide 
• 1033575-68-6 2-[2-(2-chlorophenyl)-5-trifluoromethyl-2H-pyrazol-3-yloxy]-N-(4-methoxybiphenyl-3-yl)acetamide 

Relevant articles and documents

Synthetic method for bifenazate

The invention relates to a synthetic method for bifenazate. The method comprises the following specific synthetic sections: step 1, performing nitration: mixing a 4-hydroxybiphenyl solution and a toluene solution under stirring for a reaction, and adding a HNO3 solution dropwise for a reaction to obtain a nitration reaction solution; step 2, performing methylation: mixing the nitration reaction solution and anhydrous sodium carbonate powder for a reaction, and adding a dimethyl carbonate solution dropwise for a reaction to obtain a methylation reaction solution; step 3, performing hydrogenation: throwing the methylation reaction solution, hydrogen gas, and Raney nickel into a reaction kettle for a reaction to obtain a hydrogenation reaction liquid; step 4, performing hydrazination: performing a primary hydrazination reaction, performing a secondary hydrazination reaction, performing filter pressing, performing a tertiary hydrazination reaction, and performing secondary filter pressingto obtain a condensation reaction liquid; step 5, performing condensation: mixing a third hydrazine compound, an ethyl acetate solution and an isopropyl chloroformate solution for a reaction to obtaina bifenazate mixed liquid; and step 6, performing purification: performing desolvation, performing crystallization, performing centrifugation, performing washing, performing secondary centrifugation,and performing drying to obtain the finished bifenazate. The method provided by the invention has the effect of improving purity of the bifenazate product.

Sulfonamide compound and medical applications thereof

The invention discloses a compound containing a sulfonamide structure, a preparation method thereof, and medical applications of the compound, and more specifically discloses the compound with a structure represented by formula I, and a pharmaceutically acceptable salt or a prodrug or a solvate thereof. The compound is used for tumor treatment through inhibiting ATP-citrate lyase.

Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration

Deprotonative directed ortho cupration of aromatic/heteroaromatic C-H bond and subsequent oxidation with t-BuOOH furnished functionalized phenols in high yields with high regio- and chemoselectivity. DFT calculations revealed that this hydroxylation reaction proceeds via a copper (I → III → I) redox mechanism. Application of this reaction to aromatic C-H amination using BnONH2 efficiently afforded the corresponding primary anilines. These reactions show broad scope and good functional group compatibility. Catalytic versions of these transformations are also demonstrated.

Efficient and practical cross-coupling of arenediazonium tetrafluoroborate salts with boronic acids catalyzed by palladium(0)/barium carbonate

The cross-coupling reaction of arenediazonium tetrafluoroborate salts with boronic acids catalyzed by the unusual palladium(0)/barium carbonate catalyst is described as an extremely practical and highly efficient alternative to classical homogeneous conditions. Reactions are conducted under mild conditions at room temperature without any base and ligand. The opportunity of preparing unsymmetrical terphenyls in a one-pot process is also demonstrated. Finally, the power of this methodology is highlighted by the synthesis of Bifenazate.

The discovery of bifenazate, a novel carbazate acaricide

A history of the discovery of the novel carbazate acaricide, bifenazate, is outlined. When a novel ortho-biphenyl substituted hydrazide compound showed acaricidal activity in the pesticide discovery screen, a small number of analogs were made to confirm and explore acaricidal effects. An ortho-biphenylcarbazate analog gave significantly greater acaricidal activity. Thereafter, several hundred structurally-diverse biphenylsubstituted carbazate analogs were synthesized and evaluated in a bioassay with the two-spotted spider mite (Tetranychus urticae Koch) in order to optimize the acaricidal activity. As a result of the optimization process, bifenazate, the analog with a methoxybiphenyl substituent to the terminal nitrogen atom of isopropyl carbazate, was selected for development and registration.