15860-31-8

Basic information

• Product Name: 9H-fluoren-2-yl(phenyl)methanone
• Synonyms: 9H-Fluoren-2-yl(phenyl)methanone
• CAS NO: 15860-31-8
• Molecular Formula: C₂₀H₁₄O
• Molecular Weight: 270.3246
• Mol File: 15860-31-8.mol

Chemical Properties

• Boiling Point: 463.8°C at 760 mmHg
• Flash Point: 206.2°C
• Density: 1.193g/cm³
• Vapor Pressure: 8.84E-09mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 9H-fluoren-2-yl(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-2-yl(phenyl)methanone(15860-31-8)
• EPA Substance Registry System: 9H-fluoren-2-yl(phenyl)methanone(15860-31-8)

Safety Data

• Hazardous Substances Data: 15860-31-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
9H-fluoren-2-yl(phenyl)methanone is utilized as a building block in organic synthesis for the creation of complex organic molecules due to its versatile chemical reactivity and ability to participate in various types of organic reactions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 9H-fluoren-2-yl(phenyl)methanone is used as a compound of interest for its potential biological activities, making it a valuable candidate for research in medicinal chemistry.
Used in Materials Science:
9H-fluoren-2-yl(phenyl)methanone is also employed in materials science for its potential applications in developing new materials, given its unique structural and chemical properties.

Upstream product

• 10364-94-0 1-benzoylimidazole 
• 86-73-7 9H-fluorene 
• 65-85-0 benzoic acid 
• 7446-70-0 aluminium trichloride 
• 98-88-4 benzoyl chloride 
• 153-78-6 2-aminofluorene 
• 1133-80-8 2-bromo-9H-fluorene 
• 100-47-0 benzonitrile 
• 2523-48-0 2-cyanofluorene 
• 5005-35-6 2-pyridyl benzoate 
• 100-44-7 benzyl chloride 
• 7507-40-6 9H-fluorene-2-carboxylic acid 

Downstream Products

• 96618-58-5 hydroxy-diphenyl-(fluorenyl-⁽²⁾)-methane 
• 72322-06-6 (9H-fluoren-2-yl)(phenyl)methanol 
• 20852-56-6 fluoren-2-yl-phenyl ketone oxime 
• 98257-42-2 2-(benzyl)-9H-fluorene 
• 16275-68-6 2-benzoylfluorenone 
• 1616870-40-6 C₃₂H₃₆Br₂O 
• 1616870-36-0 1,2-bis[9,9-bis(6-bromohexyl)-2-fluorenyl]-1,2-diphenylethene 
• 854750-27-9 2-(α-chloro-benzhydryl)-fluorene 
• 2116-18-9 2-Benzhydryl-fluoren 
• 858800-55-2 2-(α-iodo-benzyl)-fluorene 
• 858800-19-8 2-(α-bromo-benzyl)-fluorene 
• 5692-37-5 N,N'-fluorene-2,7-diyl-bis-benzamide 
• 578766-02-6 2,7-dibenzylfluorene 
• 69690-48-8 2,7-dibenzoyl-fluoren-9-one 

Relevant articles and documents

Ni/Ti Dual Catalytic Cross-Coupling of Nitriles and Organobromides to Access Ketones

Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel catalyst. The Ni/Ti system efficiently prepared unsymmetrical ketones with good chemoselectivity and could selectively couple a bromide in the presence of other functionalizable handles.

Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation

Erbium trifluoromethanesulfonate is found to be a good catalyst for the Friedel-Crafts acylation of arenes containing electron-donating substituents using aromatic carboxylic acids as the acylating agents under microwave irradiation. An effective, rapid and waste-free method allows the preparation of a wide range of aryl ketones in good yields and in short reaction times with minimum amounts of waste.

2-(Trifluoromethylsulfonyloxy)pyridine as a Reagent for the Ketone Synthesis from Carboxylic Acids and Aromatic Hydrocarbons

A new reagent 2-(trifluoromethylsulfonyloxy)pyridine (TFOP) was prepared by the reaction of sodium salt of 2-pyridinol with trifluoromethylsulfonyl chloride in dioxane.The conpound TFOP in trifluoroacetic acid has been found to intermolecularly dehydrate from benzoic acid and aromatic hydrocarbons to give the corresponding benzophenones in high yield.It was further elucidated, in the reaction of fluorene, that a variety of carboxylic acids can be used as the acyl precursor for the aromatic ketone synthesis in conjunction with the TFOP/TFA system.This acylation procedure has been applied to the synthesis of 2-acylthiophenes, which are hard to prepare in a satisfactory yield by the classical Friedel-Crafts reaction using aluminum chloride as the catalyst.

N-Acylimidazoles-Trifluoroacetic Acid System as the Acylating Agent for Aromatic Hydrocarbons

N-Benzoylimidazole in trifluoroacetic acid could benzoylate electron-rich aromatic compounds, such as durene, p-dimethoxybenzene, mesitylene, anisole, thiophene, and fluorene, to give the corresponding benzophenone derivatives in good yields.It was further elucidated, in the reaction of fluorene, that N-acylimidazoles composed of a variety of acyl groups also could be used for the ketone synthesis.Therein, the imidazolides of aliphatic carboxylic acids or substituted benzoic acid with an electron-donating group gave ketones in high yields.The above-mentioned aromaticcompounds were also acylated with N-trifluoroacetylimidazole and free carboxylic acids in trifluoroacetic acid.The mechanism for these reactions was assumed to proceed via a mixed anhydride between trifluoroacetic acid.