167479-51-8

Basic information

• Product Name: 2-phenylhydrazono-butyric acid ethyl ester
• Synonyms: 2-phenylhydrazono-butyric acid ethyl ester
• CAS NO: 167479-51-8
• Molecular Weight: 220.271
• Mol File: 167479-51-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenylhydrazono-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylhydrazono-butyric acid ethyl ester(167479-51-8)
• EPA Substance Registry System: 2-phenylhydrazono-butyric acid ethyl ester(167479-51-8)

Safety Data

• Hazardous Substances Data: 167479-51-8(Hazardous Substances Data)

Upstream product

• 15933-07-0 Ethyl 2-oxobutanoate 
• 100-34-5 benzene diazonium chloride 
• 34292-13-2 2-ethyl-3-oxo-butyric acid ethyl ester; sodium enolate 
• 62-53-3 aniline 
• 607-97-6 ethyl 2-ethyl-3-oxobutanoate 
• 133-13-1 ethyl diethyl malonate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 26304-51-8 ethyl 3-methyl-indole-2-carboxylate 
• 70263-59-1 2-(phenylhydrazono)butanoic acid 
• 220437-88-7 5-ethoxycarbonyl-5-ethyl-2-phenyl<1,2,4>triazolidine-3-thione 
• 61838-90-2 ethyl 1,3-dimethyl-1H-indole-2-carboxylate 

Relevant articles and documents

Synthesis and biological activity of N-(aminoiminomethyl)-1H-indole carboxamide derivatives as Na+/H+ exchanger inhibitors

A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na+/H+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7- position of the indole ring system showed that a substitution at the 2- position improved the Na+/H+ exchanger inhibitory activity the most in vitro. This led to the synthesis and evaluation of an extensive series of N- (aminoiminomethyl)-1H-indole-2-carboxamide derivatives. Derivatives having an alkyl or substituted alkyl group at the 1-position of the indole ring system showed higher levels of in vitro activities. N-(aminoiminomethyl)-1-(2- phenylethyl)-1H-indole-2-carboxamide (49) had the strongest activity.