159459-52-6Relevant articles and documents
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons
Wu, Yong-Jin,Boissard, Christopher G.,Chen, Jie,Fitzpatrick, William,Gao, Qi,Gribkoff, Valentin K.,Harden, David G.,He, Huan,Knox, Ronald J.,Natale, Joanne,Pieschl, Rick L.,Starrett Jr., John E.,Sun, Li-Qiang,Thompson, Mark,Weaver, David,Wu, Dedong,Dworetzky, Steven I.
, p. 1991 - 1995 (2007/10/03)
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcitabil