697287-41-5 Usage
Chemical Properties
White to Off-White Solid
Uses
Different sources of media describe the Uses of 697287-41-5 differently. You can refer to the following data:
1. A potent and efficacious KCNQ2 opener which inibits induced hyperexcitability of rat hippocampal neurons
2. (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide is a potent and efficacious KCNQ2 opener and found to reduce neuronal hyperexcitability in rat hippocampal slices (1).
Check Digit Verification of cas no
The CAS Registry Mumber 697287-41-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,2,8 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 697287-41:
(8*6)+(7*9)+(6*7)+(5*2)+(4*8)+(3*7)+(2*4)+(1*1)=225
225 % 10 = 5
So 697287-41-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H25FN2O2/c1-16(25-23(27)11-9-18-4-2-3-5-20(18)24)19-8-10-22-21(14-19)26(12-13-28-22)15-17-6-7-17/h2-5,8-11,14,16-17H,6-7,12-13,15H2,1H3,(H,25,27)/b11-9+/t16-/m0/s1
697287-41-5Relevant articles and documents
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons
Wu, Yong-Jin,Boissard, Christopher G.,Chen, Jie,Fitzpatrick, William,Gao, Qi,Gribkoff, Valentin K.,Harden, David G.,He, Huan,Knox, Ronald J.,Natale, Joanne,Pieschl, Rick L.,Starrett Jr., John E.,Sun, Li-Qiang,Thompson, Mark,Weaver, David,Wu, Dedong,Dworetzky, Steven I.
, p. 1991 - 1995 (2007/10/03)
(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcitabil
