477312-23-5

Basic information

• Product Name: (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine
• Synonyms: (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine
• CAS NO: 477312-23-5
• Molecular Weight: 178.234
• Mol File: 477312-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine(477312-23-5)
• EPA Substance Registry System: (+/-)-1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)ethylamine(477312-23-5)

Safety Data

• Hazardous Substances Data: 477312-23-5(Hazardous Substances Data)

Upstream product

• 26518-71-8 6-acetyl-4H-benzo[1,4]oxazin-3-one 
• 477312-20-2 6-(1-hydroxyimino-ethyl)-4H-benzo[1,4]oxazin-3-one 
• 159459-52-6 6-[1-aminoethyl]-2H-1,4-benzoxazin-3(4H)-one 

Downstream Products

• 697287-42-6 (+/-)-N-[1-(3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)acrylamide 
• 697287-41-5 (R)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide 
• 697287-41-5 N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide 

Relevant articles and documents

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl] -3-(2-fluoro-phenyl)-acrylamide ((S)-2) was identified as a potent and efficacious KCNQ2 opener. This compound demonstrated significant activity in reducing neuronal hyperexcitabil