15950-17-1

Basic information

• Product Name: (4-Chloro-2-nitro-phenyl)-Methyl-aMine
• Synonyms: (4-Chloro-2-nitro-phenyl)-Methyl-aMine
• CAS NO: 15950-17-1
• Molecular Formula: C₇H₇ClN₂O₂
• Molecular Weight: 186.59568
• EINECS: -0
• Mol File: 15950-17-1.mol
• Article Data: 17

Chemical Properties

• Melting Point: 108-109 °C
• Boiling Point: 317.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.406±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.68±0.25(Predicted)
• CAS DataBase Reference: (4-Chloro-2-nitro-phenyl)-Methyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Chloro-2-nitro-phenyl)-Methyl-aMine(15950-17-1)
• EPA Substance Registry System: (4-Chloro-2-nitro-phenyl)-Methyl-aMine(15950-17-1)

Safety Data

• Hazardous Substances Data: 15950-17-1(Hazardous Substances Data)

Usage

Uses

4-Chloro-N-methyl-2-nitroaniline is used for catalytic hydrogenation to synthesize 2-(trifluoromethyl)benzimidazole derivatives.

Upstream product

• 89-63-4 4-Chloro-2-nitroaniline 
• 77-78-1 dimethyl sulfate 
• 23042-32-2 4-chloro-N-methyl-N-nitroaniline 
• 7664-93-9 sulfuric acid 
• 64-17-5 ethanol 
• 932-96-7 N-methyl(p-chloroaniline) 
• 7782-77-6 cis-nitrous acid 
• 15249-31-7 N-phenyl-N-methyl-2-propynamide 
• 74-89-5 methylamine 
• 106-47-8 4-chloro-aniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 74-88-4 methyl iodide 
• 128691-90-7 4-chloro-2-nitrotrifluoroacetanilide 
• 693-05-0 N-(2-cyanoethyl)-N-methylamine 

Downstream Products

• 89659-70-1 (5-Chloro-2-nitro-phenyl)-methyl-carbamic acid ethyl ester 
• 57169-72-9 4-chloro-N-methyl-2,6,N-trinitro-aniline 
• 30064-10-9 5-chloro-1-methyl-2-trifluoromethylbenzimidazole 
• 107917-65-7 3-(2-aminophenyl)-6-chloro-1-methylquinoxalin-2(1H)-one 
• 103748-25-0 5-chloro-1-methyl-1H-benzimidazol-2-amine 
• 22316-47-8 clobazam 
• 22316-27-4 7-chloro-5-methyl-1-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 
• 1267634-98-9 C₂₀H₂₀ClN₃O₃ 
• 1267635-04-0 C₂₀H₂₀ClN₃O₃ 
• 20927-64-4 N-carbethoxy acetyl N-methyl 2-nitro 4-chloro aniline 
• 20927-69-9 N-Carbaethoxyacetyl-N-methyl-4-chlor-o-phenylendiamin 
• 61154-87-8 7-chloro-1-methyl-2,2-dioxo-5-phenyl-1,2,3,5-tetrahydro-2λ⁶-benzo[c][1,2,5]thiadiazepin-4-one 
• 154003-66-4 (S)-(+)-N-<4-Chlor-2-nitro-phenyl>-N-methyl-butyl-methyl-malonsaeurediamid 
• 153899-90-2 N-<4-Chlor-2-nitro-phenyl>-N-methyl-butyl-methyl-malonsaeurediamid 

Relevant articles and documents

Selective one-pot N-monomethylation of 2-nitroanilines under PTC conditions

Direct PTC methylation of 2-nitroanilines with dimethyl sulfate gave selectively N-monomethylated products. A variety of N-methyl-2-nitroanilines were prepared in this way.

Oxidative Radical Cyclization of N-methyl-N-arylpropiolamide to Isatins via Cleavage of the Carbon-carbon Triple Bond

A radical cyclization of N-methyl-N-arylpropiolamide to isatins via an oxidative cleavage of a carbon-carbon triple bond has been developed. In the presence of oxone and NaNO2, a variety of N-methyl-N-arylpropiolamides were smoothly transformed into isatins. A nitration reaction proceeded along with the oxidative cyclization; both nitrated and non-nitrated isatins were obtained in a one-pot reaction with moderate to good total yields. This is the first example for the synthesis of isatins via the oxidative radical cleavage of a carbon-carbon triple bond. (Figure presented.).

Amino Azaxylylenes Photogenerated from o-Amido Imines: Photoassisted Access to Complex Spiro-Poly-Heterocycles

Upon irradiation, cyclic imines containing o-amido groups are shown to produce reactive intermediates, amino azaxylylenes, which undergo intramolecular cycloadditions to tethered unsaturated pendants to yield complex N,O-heterocycles having an additional spiro-connected nitrogen heterocyclic moiety. Modular assembly of the photoprecursors allows expeditious increase of the complexity of the target poly-heterocyclic scaffolds with a minimal number of experimentally simple reaction steps. The photocyclization and subsequent postphotochemical transformations are accompanied by an increase of Lovering's fsp3 factor, thus producing unprecedented three-dimensional molecular architectures, and offering extended sampling of chemical space. Rings in three dimensions: Cyclic imines containing an o-amido group undergo excited-state intramolecular proton transfer to generate amino azaxylylenes. The amino azaxylylenes undergo intramolecular cycloadditions to tethered unsaturated pendants to yield complex heterocyclic three-dimensional molecular architectures.