15965-66-9

Upstream product

• 66108-85-8 1-methyl-5-nitro-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 5381-78-2 1-methyl-5-nitro-1H-benzo[d]imidazole 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 21395-42-6 3-acetyl-1-methyl-5-nitro-1,3-dihydro-benzoimidazol-2-one 
• 41939-61-1 N₁-methyl-4-nitrobenzene-1,2-diamine 
• 596131-59-8 1-methyl-5-nitro-1,3-dihydro-benzimidazole-2-thione 
• 5955-72-6 2-chloro-5-nitro-1H-benzo[d]imidazole 
• 74-88-4 methyl iodide 

Downstream Products

• 203302-75-4 6-amino-2-chloro-1-methyl-1H-benzimidazole 
• 203302-74-3 2-chloro-1-methyl-1H-benzoimidazol-5-ylamine 

Relevant academic research and scientific papers

Synthesis of benzo[1,2-d;3,4-d′]diimidazole and 1H-pyrazolo[4,3-b] pyridine as putative A2A receptor antagonists

The synthesis and the binding affinity for the putative adenosine receptor antagonist 6-methyl-7-[1,2,3]triazol-2-yl-1,6-dihydrobenzo[1,2-d;3,4-d′] diimidazole (10) and 5-oxazol-2-yl-1H-pyrazolo[4,3-b]pyridin-3-ylamine (16) are reported. The title compounds were prepared from commercially available 1-chloro-2,4-dinitrobenzene (1) and 2-chloro-6-methoxy-3nitropyridine (11), respectively, but proved devoid of affinity for the adenosine A1 and A2A receptors. The Royal Society of Chemistry.

BICYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the formula (1) are useful as MCH mediator, and in the therapy of obesity.

DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS

Benzimidazole derivatives of formula (I) , which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatme

Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula wherein Ra to Rc, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein Rc denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.

Pyridinium Betaines Derived from Thiazolo and Imidazoacridinones

Four betaines derived from imidazo[4,5-a], imidazo[5,4-a] and thiazolo[5,4-a]acridine have been prepared in a six step procedure starting from 2-chlorobenzimidazoles and benzothiazoles. The 1H and 133C nmr has been used to characteri