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66108-85-8

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66108-85-8 Usage

General Description

2H-Benzimidazol-2-one, 1,3-dihydro-1-methyl-5-nitro-(9CI) is a chemical compound that is a derivative of benzimidazole. It is a heterocyclic compound with a nitro group and a methyl group attached to the benzimidazole ring. 2H-Benzimidazol-2-one,1,3-dihydro-1-methyl-5-nitro-(9CI) has potential biological activity and has been studied for its use in pharmaceuticals and as a building block in organic synthesis. It has been found to exhibit anti-inflammatory and anti-tumor properties, making it a compound of interest in the development of new drug molecules. Additionally, its unique structure makes it valuable for medicinal chemistry research and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 66108-85-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,0 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 66108-85:
(7*6)+(6*6)+(5*1)+(4*0)+(3*8)+(2*8)+(1*5)=128
128 % 10 = 8
So 66108-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H7N3O3/c1-10-7-3-2-5(11(13)14)4-6(7)9-8(10)12/h2-4H,1H3,(H,9,12)

66108-85-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Methyl-5-nitro-2,3-dihydro-1H-1,3-benzodiazol-2-one

1.2 Other means of identification

Product number -
Other names 3-methyl-6-nitro-1H-benzimidazol-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66108-85-8 SDS

66108-85-8Relevant articles and documents

Reactions of 1-methylbenzimidazole derivatives with m-chloroperoxybenzoic acid

Kaiya, Toyo,Aoyama, Shinsuke,Kohda, Kohfuku

, p. 625 - 630 (1998)

Oxidation of seven 1-methylbenzimidazole (MBI) derivatives (with pKa's ranging from 1.6 to 6.0) was carried out with m-chloroperoxybenzoic acid and structures of the products formed were identified. (Condensed benzene moiety-hydroxylated)-2-(m-chlorobenzyloxy)-MBIs and 2-oxo-MBIs were obtained from MBIs with pKa's of more than 5.6 and about 3.3, respectively.

Achieving in Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

Bellenie, Benjamin R.,Cheung, Kwai-Ming J.,Varela, Ana,Pierrat, Olivier A.,Collie, Gavin W.,Box, Gary M.,Bright, Michael D.,Gowan, Sharon,Hayes, Angela,Rodrigues, Matthew J.,Shetty, Kartika N.,Carter, Michael,Davis, Owen A.,Henley, Alan T.,Innocenti, Paolo,Johnson, Louise D.,Liu, Manjuan,De Klerk, Selby,Le Bihan, Yann-Va?,Lloyd, Matthew G.,McAndrew, P. Craig,Shehu, Erald,Talbot, Rachel,Woodward, Hannah L.,Burke, Rosemary,Kirkin, Vladimir,Van Montfort, Rob L. M.,Raynaud, Florence I.,Rossanese, Olivia W.,Hoelder, Swen

, p. 4047 - 4068 (2020/04/20)

Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery of a series of benzimidazolone inhibitors of the protein-protein interaction between BCL6 and its co-repressors. A subset of these inhibitors were found to cause rapid degradation of BCL6, and optimization of pharmacokinetic properties led to the discovery of 5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CCT369260), which reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.

Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals

-

, (2008/06/13)

The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula wherein Ra to Rc, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. The compounds of the above formula I wherein Rc denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein Rc denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.

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