159754-77-5Relevant academic research and scientific papers
A synthetic method of the compound animal pen ether class
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Paragraph 0123; 0124; 0125; 0126; 0127-0134, (2017/04/27)
The invention relates to a synthetic method of a benzyl ether compound. The synthetic method is used for avoiding environmental pollution caused by conventional benzyl ether compound synthetic methods. The synthetic method comprises following steps: step 1, a benzyl silane compound, an oxidizing agent, and a light reaction catalyst are delivered into a reactor, the reactor is vacuumized, and is filled with nitrogen for protection, an alkali compound and an alcohol reagent are delivered into the reactor through syringes, the reactor is exposed to visible light, reaction is carried out at room temperature with magnetic stirring, after reaction, an obtained reaction solution is filtered, and a liquid obtained via filtration is subjected to condensation so as to remove solvents and obtain a concentrated solution; and step 2, the concentrated solution is subjected to silica-gel column chromatography for separation and purification so as to obtain the benzyl ether compound, wherein a mixed solution of petroleum ether and ethyl acetate is taken as an eluent. Reaction conditions are mild; operation is simple and convenient; reaction yield is high; and the maximum reaction yield can be 93%.
Metalation of arylmethyl alkyl ethers
Azzena, Ugo,Pilo, Luciano,Sechi, Alessandra
, p. 12389 - 12398 (2007/10/03)
Arylmethyl alkyl ethers 1a-11 were metallated with n-BuLi or sec-BuLi in THF at different temperatures, affording α-alkoxy-substituted arylmethyllithium derivatives. At low temperature, the organometallics derived from methyl and isopropyl ethers are suff
Metalation of Arylmethyl Methyl Ethers and Connection with Their Reductive Electrophilic Substitution
Azzena, Ugo,Demartis, Salvatore,Fiori, Maria Giovanna,Melloni, Giovanni,Pisano, Luisa
, p. 5641 - 5644 (2007/10/02)
Stable α-methoxy arylmethyl carbanions can be generated by metalation of arylmethyl methyl ethers, 1, with n-BuLi in THF at -40 degC, avoiding Wittig rearrengement to the corresponding alkoxides 2.Reaction of these carbanions with various electrophiles afforded the expected products 3 in satisfactory yields.Connection between the metalation procedure and the reductive electrophilic substitution of arylmethyl methyl ethers allowed the transformation of compounds 1 into 2-arylpropanoic acids, 5.
