21998-86-7

Basic information

• Product Name: 2-(Methoxymethyl)anisole
• Synonyms: (2-Methoxybenzyl)methyl ether;1-Methoxy-2-(methoxymethyl)benzene;1-Methoxy-2-methoxymethylbenzene;2-(Methoxymethyl)anisole;2-Methoxybenzylmethyl ether;Methyl(2-methoxybenzyl) ether
• CAS NO: 21998-86-7
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.1904
• Mol File: 21998-86-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 192°Cat760mmHg
• Flash Point: 61.2°C
• Appearance: /
• Density: 0.997g/cm³
• Vapor Pressure: 0.694mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 2-(Methoxymethyl)anisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methoxymethyl)anisole(21998-86-7)
• EPA Substance Registry System: 2-(Methoxymethyl)anisole(21998-86-7)

Safety Data

• Hazardous Substances Data: 21998-86-7(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Usage

Flavoring agent in the food industry, production of perfumes and fragrances, synthesis of pharmaceuticals and agrochemicals

Aroma

Sweet and creamy

Color

Colorless to pale yellow

Odor

Pleasant

Properties

Insecticidal, antibacterial

InChI:InChI=1/C9H12O2/c1-10-7-8-5-3-4-6-9(8)11-2/h3-6H,7H2,1-2H3

Upstream product

• 578-57-4 2-bromoanisole 
• 27490-32-0 tributyl(methoxymethyl)stannane 
• 90-01-7 salicylic alcohol 
• 77-78-1 dimethyl sulfate 
• 107-30-2 chloromethyl methyl ether 
• 910251-11-5 potassium trifluoro(methoxymethyl)boranuide 
• 766-51-8 2-Chloroanisole 
• 67-56-1 methanol 
• 99522-22-2 o-(trimethylsilylmethyl)benzyl alcohol 
• 606-45-1 2-methoxybenzoic acid methyl ester 
• 1441-87-8 salicyloyl chloride 
• 69-72-7 salicylic acid 
• 90-02-8 salicylaldehyde 
• 612-16-8 (2-methoxyphenyl)methanol 

Downstream Products

• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 13513-82-1 1-(2-methoxyphenyl)ethanol 
• 159754-77-5 1-methoxy-2-(1-methoxypentyl)benzene 
• 22800-73-3 α-methyl-o-methoxybenzyl methyl ether 
• 99232-40-3 C₈H₉CsO 
• 99232-41-4 C₈H₉KO 
• 99232-42-5 o-anisyllithium 
• 125258-70-0 o-methoxy-N,O-dimethylhalostachine 

Relevant articles and documents

An Application of nJ(CH2,H) and 5J(OH,H) Long-Range Couplings in the Conformational Analysis of 2-Hydroxybenzyl Methyl Ether in Various Solvents. Computational Strategies for Spectral Analysis and Determination of Association Thermod

1H NMR spectra of 2-hydroxy- and 2-methoxy-benzyl methyl ethers were measured in various solvents and solvent mixtures.Precise nJ(CH2,H), where n = 4, 5 or 6, and 5J(OH,H) long-range couplings were applied to the characterization of

Methoxymethylation and benzyloxymethylation of aryl bromides

The methoxymethylation and benzyloxymethylation of aryl bromides methodology was reported here. The transition metal free, high yielding one pot procedure will be useful for synthetic community.

Lewis acid promoted ruthenium(II)-catalyzed etherifications by selective hydrogenation of carboxylic acids/esters

Ethers are of fundamental importance in organic chemistry and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds. In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity. An assist from Al: A bifunctional catalyst system consisting of a Ru/phosphine complex and aluminum triflate allows selective hydrogenation of esters to ethers. A variety of lactones were reduced to the desired products in good yields. The catalyst further provides a general method for the reduction of linear esters and reductive etherification of carboxylic acids with alcohols.