159768-50-0

Usage

Uses

Used in Organic Synthesis:
Methyl 4-fluoro-5-methoxy-2-nitrobenzoate is used as an intermediate in organic synthesis for the production of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Methyl 4-fluoro-5-methoxy-2-nitrobenzoate is used as a starting material for the development of new drugs. Its distinct chemical properties and potential biological activity make it a promising candidate for the creation of novel therapeutic agents.
Used in Chemical Research:
Methyl 4-fluoro-5-methoxy-2-nitrobenzoate is also utilized in chemical research to study the effects of fluoro and methoxy substituents on the reactivity and properties of benzene derivatives. This can lead to a better understanding of structure-activity relationships and the development of new synthetic methods.
It is important to handle Methyl 4-fluoro-5-methoxy-2-nitrobenzoate with care due to its classification as a nitro compound, which may have associated health hazards. Proper safety measures should be taken to minimize any potential risks during its use in various applications.

Upstream product

• 159768-48-6 4-chloro-7-fluoro-6-methoxyquinazoline 
• 7664-93-9 sulfuric acid 
• 74385-37-8 methyl 4-fluoro-3-methoxy-benzoate 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 

Downstream Products

• 159768-51-1 2-amino-4-fluoro-5-methoxybenzoic acid methyl ester 
• 869475-52-5 7-fluoro-6-methoxyquinazolin-4-ol 
• 159768-48-6 4-chloro-7-fluoro-6-methoxyquinazoline 
• 162012-60-4 4-(3-chloro-4-fluoroanilino)-6-methoxy-7-fluoroquinazoline 

Relevant academic research and scientific papers

Pyrazole derivative for FGFR inhibitor and preparation method of pyrazole derivative

The invention provides a pyrazole derivative for an FGFR inhibitor and a preparation method of the pyrazole derivative. The invention specifically relates to an amide pyrazole compound serving as an FGFR irreversible inhibitor, and a preparation method and application thereof. The present invention provides a compound as shown in Formula I, or a pharmaceutically acceptable salt, or solvate, isotope substitute, prodrug, or metabolite thereof. The compound as shown in general formula I have FGFR inhibitory activity, and is capable of preventing or treating disorders associated with FGFR activityor expression, preferably such as cancer.

BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS

Described herein are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R 4, Y1, Y2, n and p are as defined herein.

Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors

Fibroblast growth factor receptors (FGFRs) are important oncology targets due to the dysregulation of this signaling pathway in a wide variety of human cancers. We identified a series of pyrazolylaminoquinazoline derivatives as potent FGFR inhibitors with low nanomolar potency. The representative compound 29 strongly inhibited FGFR1-3 kinase activity and suppressed FGFR signaling transduction in FGFR-addicted cancer cells; FGFRs-driven cell proliferation was also strongly inhibited regardless of mechanistic complexity implicated in FGFR activation, which further confirmed that 29 was a potent pan-FGFR inhibitor. The flexibility of our structure offered the potential to preserve good affinity for mutant FGFR, which is important for developing TKIs with long-term efficacy.

QUINAZOLINONE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a novel compound having effects on 5-HT5A receptor and useful as a therapeutic agent and/or a preventive agent of psychiatric disorders and neurodegenerative diseases to which 5-HT5A receptor relates such as schizophrenia,

Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core

The facile preparation of 4-(3-chloro-4-fluoroanilino)-6-alkoxy-7- aminoquinazolines from their corresponding 7-triflate and 7-fluoro precursors are highlighted.

Quinazoline derivatives

The invention concerns quinazoline derivatives of the formula I STR1 wherein R 1 includes hydroxy, amino, hydroxyamino, (1-4C)alkoxy, (1-4C)alkylamino and di-[(1-4C)alkyl]amino;R 3 is halogeno;n is 1, 2 or 3 and R 2 includes hydrogen, hydroxy, halogeno and (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof;processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.