15979-82-5

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 108-44-1 1-amino-3-methylbenzene 
• 621-29-4 3-tolyl isocyanate 
• 625-95-6 3-Iodotoluene 
• 100-01-6 4-nitro-aniline 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 26760-22-5 methyl p-nitrobenzenesulphinate 
• 108-39-4 3-methyl-phenol 
• 1798-11-4 4-nitrophenoxyacetic acid 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 392237-47-7 2-(4-nitro-phenoxy)-N-m-tolyl-acetamide 

Downstream Products

• 225381-71-5 N-(6-phenyl-thieno[3,2-d]pyrimidin-4-yl)-N'-m-tolyl-benzene-1,4-diamine 
• 42771-90-4 N¹-(m-tolyl)benzene-1,4-diamine 

Relevant academic research and scientific papers

Diarylamine Synthesis via Desulfinylative Smiles Rearrangement

Diarylamines are obtained directly from sulfinamides through a novel rearrangement sequence. The transformation is transition metal-free and proceeds under mild conditions, providing facile access to highly sterically hindered diarylamines that are otherw

Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.

Smiles rearrangement for the synthesis of diarylamines

A protocol for the one-pot synthesis of diarylamines via Smiles rearrangement under microwave irradiation has been developed. Various diarylamines were effectively synthesized starting from readily available substituted phenols, arylamines and chloroacetyl chloride in moderate to good yields (58-92%). ARKAT-USA, Inc.

A convenient preparation of N-alkyl and N-arylamines by smiles rearrangement - Synthesis of analogues of diclofenac

Smiles rearrangement of substituted aryloxyacetamides in which oxygen and nitrogen are separated by COCH2 group has been successful even when the aryloxy ring carries weak or no electron withdrawing group. Earlier reports of such reactions involved either strong electron withdrawing groups or a special catalyst. The diphenylamines thus obtained gave analogues of diclofenac in only one case.

Thienopyrimidine and thienopyridine derivatives useful as anticancer agents

The invention relates to compounds of the formulas 1 and 2 and to pharmaceutically acceptable salts and hydrates thereof, wherein X1, R1, R2and R11are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1 and 2 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formulas 1 and 2.

Process for the preparation of nitro diphenyl amine derivatives

A process for the preparation of nitro-diphenyl amines is disclosed by decarboxylation of a urethane in the presence of a base at an elevated temperature using tetramethylene sulphone as reaction medium is disclosed. The urethane can be one formed by the reaction of a nitrophenol with an aromatic isocyanate.