159802-98-9Relevant academic research and scientific papers
Efficient desymmetrization of 4,6-di-O-benzyl-myo-inositol by Lipozyme TL-IM
Vasconcelos, Marcela G.,Briggs, Raissa H.C.,Aguiar, Lucia C.S.,Freire, Denise M.G.,Simas, Alessandro B.C.
, p. 7 - 11 (2014)
The enantioselective enzymatic desymmetrization of 4,6-di-O-benzyl-myo- inositol, a myo-inositol derivative, was effectively catalyzed by Thermomyces lanuginosus lipase (TL-IM). The product 1D-1-O-acetyl-4,6-di-O-benzyl-myo- inositol, a useful precursor t
Development of isotope-enriched phosphatidylinositol-4- And 5-phosphate cellular mass spectrometry probes
Joffrin, Amélie M.,Saunders, Alex M.,Barneda, David,Flemington, Vikki,Thompson, Amber L.,Sanganee, Hitesh J.,Conway, Stuart J.
, p. 2549 - 2557 (2021/03/01)
Synthetic phosphatidylinositol phosphate (PtdInsPn) derivatives play a pivotal role in broadening our understanding of PtdInsPnmetabolism. However, the development of such tools is reliant on efficient enantioselective and regioselective synthetic strategies. Here we report the development of a divergent synthetic route applicable to the synthesis of deuterated PtdIns4Pand PtdIns5Pderivatives. The synthetic strategy developed involves a key enzymatic desymmetrisation step using Lipozyme TL-IM. In addition, we optimised the large-scale synthesis of deuteratedmyo-inositol, allowing for the preparation of a series of saturated and unsaturated deuterated PtdIns4Pand PtdIns5Pderivatives. Experiments in MCF7 cells demonstrated that these deuterated probes enable quantification of the corresponding endogenous phospholipids in a cellular setting. Overall, these deuterated probes will be powerful tools to help improve our understanding of the role played by PtdInsPnin physiology and disease.
Kinetic resolution of d,l-myo-inositol derivatives catalyzed by chiral Cu(II) complex
Matsumura, Yoshihiro,Maki, Toshihide,Tsurumaki, Kazuya,Onomura, Osamu
, p. 9131 - 9134 (2007/10/03)
Kinetic resolution of d,l-myo-inositol derivatives having a 1,2-diol functionality by monobenzoylation was achieved using (R,R)-Ph-BOX-Cu(II) as a catalyst. The monobenzoylation preferentially took place at the 1,2-diol functionality via a highly enantiod
