15982-61-3Relevant articles and documents
Design and synthesis of novel triazole linked pyrrole derivatives as potent Mycobacterium tuberculosis inhibitors
Devi, M. Lakshmi,Reddy, P. Lakshmi,Yogeeswari,Sriram,Reddy, T. Veera,Reddy, B. V. Subba,Narender
, p. 2985 - 2999 (2017)
This research is focused on the rational approach to design and synthesis of a novel series of triazole linked pyrrole derivatives through a sequential Paal–Knorr reaction and Click chemistry. These new molecules were screened against Mycobacterium tuberculosis H37Rv and found to display promising anti-mycobacterial activity. Among various compounds, 7g and 7l were identified as leads with minimum inhibitory concentration value 0.78 (μg/mL), which are more effective than standard drugs such as pyrazinamide, ethambutol, and ciprofloxacin and less active than isoniazid and rifampicin. These molecules (minimum inhibitory concentration values 12.5 μg/mL) were also screened against HEK-293T cancer cell lines. Most of these molecules are less toxic but possess higher selectivity index, which indicates the suitability of these compounds for further evaluation.
Samarium-promoted michael addition between aroyl chlorides and chalcones
Liu, Yongjun,Li, Yuanying,Qi, Yan,Wan, Jun
experimental part, p. 4188 - 4192 (2011/02/25)
A novel Michael addition type reaction between aroyl chlorides and chalcones was realized in the presence of samarium metal when N,N-dimethylformamide was used as a solvent. A variety of 1,4-diketones were thereby synthesized in moderate to good yields. T
A new method for the synthesis of acyltitanium complexes and their application to copper-mediated acylmetallation of carbon-carbon multiple bonds in aqueous media
Han, Zhenfu,Fujioka, Takuma,Usugi, Shin-Ichi,Yorimitsu, Hideki,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 1622 - 1623 (2007/10/03)
Treatment of α,β-unsaturated carbonyl compounds or methyl propargyl ether with acylchlorobis(cyclopentadienyl)titanium in the presence of Methylamine and a copper salt in aqueous THF resulted in acylation of the carbon-carbon multiple bond, yielding the c
