15229-65-9

Upstream product

• 2214-82-6 Bis(dimethylamino)acetonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 
• 124-40-3 dimethyl amine 

Downstream Products

• 101781-04-8 dimethyl-(3-phenyl-1-p-tolyl-propyl)-amine 
• 128407-44-3 (Z)-2-Dimethylamino-3-methylsulfanyl-5-phenyl-5-piperidin-1-yl-2-p-tolyl-pent-4-enenitrile 
• 128407-41-0 (Z)-2,5-Bis-dimethylamino-3-methylsulfanyl-2,5-di-p-tolyl-pent-4-enenitrile 
• 128407-42-1 (Z)-2-Dimethylamino-5-morpholin-4-yl-3,5-diphenyl-2-p-tolyl-pent-4-enenitrile 
• 116858-52-7 (Z)-2,5-Bis-dimethylamino-3-phenyl-2,5-di-p-tolyl-pent-4-enenitrile 
• 101707-69-1 2-Dimethylamino-4,4-diethoxy-2-p-tolyl-butyronitrile 
• 116858-55-0 (1Z,3Z)-N,N,N',N'-Tetramethyl-1,4-di-p-tolyl-buta-1,3-diene-1,4-diamine 
• 59843-75-3 3-p-tolyl-1H-pyrazole 
• 128407-51-2 2-Dimethylamino-5-oxo-3,5-diphenyl-2-p-tolyl-pentanenitrile 
• 128407-57-8 2-Methylsulfanyl-4-phenyl-1-p-tolyl-butane-1,4-dione 
• 13145-56-7 1,4-bis(4-tolyl)butane-1,4-dione 
• 116858-56-1 2-Dimethylamino-5-oxo-3-phenyl-2,5-di-p-tolyl-pentanenitrile 
• 15982-61-3 1,4-di(4-methylphenyl)-2-phenyl-1,4-butandione 
• 128407-34-1 2-Dimethylamino-3-ethoxy-2-p-tolyl-but-3-enenitrile 

Relevant academic research and scientific papers

One-pot, solvent-free synthesis of α-aminonitriles under catalysis by magnesium bromide ethyl etherate

A three-component, efficient, and facile procedure has been developed for the synthesis of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide using a catalytic amount of magnesium bromide ethyl etherate in the absence of solvent. Rapid formation of products is observed at room temperature in a one-pot procedure under very mild conditions giving excellent yields of the title compounds.

Orthoamides, XXXIII.-Contributions to the Chemistry of Bis(dialkylamino)acetonitriles

Bis(dialkylamino)acetonitriles 2a-d react with acetyl chloride and antimony pentachloride to give N,N,N',N'-tetraalkylformamidinium hexachloroantimonates 5a-d.Reaction of p-nitrophenol with 2a,b affords N,N,N',N'-tetraalkylformamidinium salts 8a,b, while reaction of aromatic aldehydes 11 with compounds 2 gives aryl(dialkylamino)acetonitriles 12.Phenyl isothiocyanate reacts with the nitriles 2a-c to give 1:1 adducts for which the structure of N,N,N',N'-tetraalkylformamidinium cyano-N-(phenyl)thioformamidates 19 is proposed.N,N,N',N'-Tetraalkylformamidinium p-toluenesulfonates 30a,b have been prepared from nitriles 2a,b and methyl p-toluoenesulfonate (28).Alkylation of 2c with 28 at higher temperatures affords 1,1-dimethylpiperidinium p-toluoenesulfonate (34) and a small amount (1-piperidinyl)malonodinitrile (33).The nitrile 2a reacts with CH acidic compounds such as ethyl cyanoacetate, malonodinitrile and benzyl cyanide to form the enamines 38.