1598431-99-2Relevant academic research and scientific papers
Copper-Catalyzed Synthesis of Trifluoroethylarenes from Benzylic Bromodifluoroacetates
Ambler, Brett R.,Zhu, Lingui,Altman, Ryan A.
, p. 8449 - 8457 (2015/09/01)
Trifluoroethylarenes are found in a variety of biologically active molecules, and strategies for accessing this substructure are important for developing therapeutic candidates and biological probes. Trifluoroethylarenes can be directly accessed via nucleophilic trifluoromethylation of benzylic electrophiles; however, current catalytic methods do not effectively transform electron-deficient substrates and heterocycles. To address this gap, we report a Cu-catalyzed decarboxylative trifluoromethylation of benzylic bromodifluoroacetates. To account for the tolerance of sensitive functional groups, we propose an inner-sphere mechanism of decarboxylation.
Copper-promoted reductive coupling of aryl iodides with 1,1,1-trifluoro-2-iodoethane
Xu, Song,Chen, Huan-Huan,Dai, Jian-Jun,Xu, Hua-Jian
supporting information, p. 2306 - 2309 (2014/05/20)
An efficient Cu-promoted reductive coupling of aryl iodides with 1,1,1-trifluoro-2-iodoethane has been developed. This reaction could occur in good yields under milder conditions as compared with previous studies. The reaction tolerated nitro, formyl, ester, ether, carbonyl, sulfonyl, and even azo groups.
