159848-77-8

Upstream product

• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 696-62-8 para-iodoanisole 
• 140-88-5 ethyl acrylate 
• 529-28-2 4-iodoanisol 
• 123-11-5 4-methoxy-benzaldehyde 
• 182187-05-9 (2S,3R)-3-Acetoxy-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid ethyl ester 

Downstream Products

• 439828-88-3 (2S,3R)-trans-(4-methoxyphenyl)glycidic acid ethyl ester 
• 220736-25-4 (+)-(4S,5S)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 
• 780795-87-1 (2S,3S)-3-Azido-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid ethyl ester 
• 220736-25-4 (4R,5S)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one 
• 130796-31-5 (4S,5R)-trans-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde 
• 159848-85-8 (3S,3'S)-3--3-(4-methoxyphenyl)-1-(2,2,2-trichloroethoxycarbonyloxy)propane 
• 159848-87-0 (3S,3'S)-3-<3'-acetoxy-N-tert-butoxycarbonyl-3'-(4-methoxyphenyl)propylamino>-3-(4-methoxyphenyl)-1-(2,2,2-trichloroethoxycarbonyloxy)propane 

Relevant academic research and scientific papers

RAS INHIBITORS

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Preparation, characterization and catalytic properties of polyaniline-supported metal complexes

Polyaniline-supported Sc, In, Pd, Os and Re catalysts were prepared by using a simple protocol and the thus prepared catalysts were well characterized using FTIR, XPS, UV-Vis/DRS, TGA-DTA. All the catalysts were successfully employed in a wide range of organic transformations such as cyanation and allylation of carbonyl compound, Suzuki coupling of aryl halides and boronic acids, and, most importantly, in asymmetric dihydroxylation of olefins to afford optically active vicinal diols. All the catalysts were separated from the reaction mixture by simple filtration and reused with consistent activity for five cycles without noticeable leaching of metal from the support.

Bifunctional catalysts stabilized on nanocrystalline magnesium oxide for one-pot synthesis of chiral diols

New bifunctional catalysts composed of PdCl42-, OsO42- and OsO42-, WO 42- designed and prepared by a counterionic stabilization technique involving the reactions of Na2PdCl4-K 2OsO4 and K2OsO4-Na 2WO4 with nanocrystalline MgO are well characterized. These bifunctional catalysts, NAP-Mg-PdOs and NAP-Mg-OsW perform tandem Heck asymmetric dihydroxylation and asymmetric dihydroxylation-N-oxidation reactions, respectively, in the presence of the chiral ligand 1,4-bis(9-o- dihydroquinidinyl)phthalazine [(DHQD)2PHAL] in a single pot. It is quite impressive to note that H2O2 is used as a terminal oxidant to provide N-methylmorpholine N-oxide (NMO) in situ by the oxidation of N-methylmorpholine (NMM) in the asymmetric dihydroxylation-N-oxidation catalyzed by NAP-Mg-OsW.

Highly regioselective ring opening of epoxides using NaN3: A short and efficient synthesis of (-)-cytoxazone

A convenient and efficient synthesis of 1,2-azido alcohols has been achieved by regioselective ring opening of epoxides using NaN3 and 4 ? molecular sieves in acetonitrile. The utility of this method has been demonstrated by achieving a short synthesis of (-)-cytoxazone in 48% overall yield.

A trifunctional catalyst for one-pot synthesis of chiral diols via heck coupling-N-oxidation-asymmetric dihydroxylation: Application for the synthesis of diltiazem and taxol side chain

A heterogeneous bifunctional catalyst composed of OsO42--WO42- and a trifunctional catalyst comprising PdCl42--OsO42-- WO42-, designed and prepared by an ion-exchange technique using layered double hydroxides (LDH) as an ion-exchanger and their homogeneous bifunctional analogue, K2OsO4-Na2WO4 and trifunctional analogue, Na2PdCl4-K2OsO4-K2 OSO4-NNa2WO4, devised for the first time are evaluated for the synthesis of chiral vicinal diols. These bifunctional and trifunctional catalysts perform asymmetric dihydroxylation-N-oxidation and Heck-asymmetric dihydroxylation-N-oxidation, respectively, in the presence of Sharpless chiral ligand, (DHQD)2PHAL in a single pot using H2O2 as a terminal oxidant to provide N-methylmorpholine oxide (NMO) in situ by the oxidation of N-methylmorpholine (NMM). The heterogeneous bifunctional catalyst supported on LDH (LDH-OsW) displays superior activity to afford diols with higher yields over the other heterogeneous catalysts developed by the ion exchange on quaternary ammonium salts covalently bound to resin (resin-OsW) and silica (silica-OsW) or homogeneous catalysts in the achiral dihydroxylation reactions. The LDH-OsW and its homogeneous analogue are found to be very efficient in performing a simultaneous asymmetric dihydroxylation (AD)-N-oxidation of a wide and varied range of aromatic, cyclic, and mono, di-, and trisubstituted olefins to obtain chiral vicinal diols with higher yields and ee's using H2O2. Further, the use of OsO42--WO42-- WO42- catalysts as such or in the supported form offers a simplified procedure for catalyst recycling, which shows consistent activity for a number of cycles. In this process, OsVI is recycled to OsVIII by a coupled electron transfer-mediator (ETM) system based on NMO-WO42- using H2O2, leading to a mild and selective electron transfer. The one-pot biomimic synthesis of chiral diols is mediated by a recyclable trifunctional heterogeneous catalyst (LDH-PdOsW) consisting of active palladium, tungsten, and osmium species embedded in a single matrix. This protocol, which provides prochiral olefins and NMO in situ by Heck coupling and N-oxidation of NMM, respectively, required for the AD, unfolds a low cost process. We extended the present method to the one-pot synthesis of trisubstituted chiral vicinal diols with moderate to excellent ee's by AD of trisubstituted olefins that are obtained by in situ Heck arylation of disubstituted olefins. The heterogeneous trifunctional catalysts offers chiral diols with unprecedented ee's and excellent yields in the AD of prochiral cinnamates, which are obtained in situ from acrylates and halobenzenes for the first time. The new variants such as LDH support and Et3N·HX inherently composed in the heterogeneous multicomponent system and slow addition of H202 facilitates the hydrolysis of osmium monogylcolate ester to subdue the formation of bisglycolate ester to achieve higher ee's. Without resorting to recrystallization, the chiral diols of cinnamates thus synthesized with 99% ee's and devoid of osmium contamination are directly put to use in the synthesis of diltiazem and Taxol side chain with an overall improved yield to demonstrate the synthetic utility of the trifunctional heterogeneous catalyst. The high binding ability of the heterogeneous osmium catalyst enables the use of equimolar ratio of ligand to osmium to give excellent ee's in AD in contrast to the homogeneous osmium system in which the excess molar quantities of the expensive chiral ligand to osmium are invariably used. Further, the XRD, FT-IR, UV-vis DRS, and XPS studies indicate the retention of the coordination geometries of the specific divalent anions anchored to LDH matrix in their monomeric form during the ion exchange and after the reaction.

Osmium tetroxide in poly(ethylene glycol) (PEG): A recyclable reaction medium for rapid asymmetric dihydroxylation under Sharpless conditions

PEG (400) has been used as a recyclable and rapid reaction medium for the asymmetric dihydroxylation of olefins; Sharpless ligand is efficiently recovered and recycled with good enantioselectivity.

Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof, and process for the preparation of chiral vicinal diols using said multifunctional catalysts

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are usef

Multifunctional catalyst useful in the synthesis of chiral vicinal diols and process for the preparation thereof

The present invention relates to a multifunctional reusable catalyst and to a process for the preparation thereof on a single matrix of the support to perform multicomponent reaction in a single pot. The multifunctional catalysts of the invention are useful for the synthesis of chiral vicinal diols by tandem and / or simultaneous reactions involving Heck coupling, N-oxidation and AD reaction of olefins in presence of cinchona alkaloid compounds both as an native one and immobilized one in the said matrix support. This invention also relates to a process for preparing vicinal diols by asymmetric dihydroxylation of olefins in presence of cinchona alkaloid compounds employing reusable multifunctional catalysts as heterogeneous catalysts in place of soluble osmium catalysts.

Silica Gel-Supported Cinchona Alkaloid-OsO4 Complex for Catalytic Heterogeneous Asymmetric Dihydroxylation of Olefins by H2O2 using a Titanium Silicalite-Based Coupled Catalytic System

A triple catalytic system designed for asymmetric dihydroxylation of olefins, composed of NMM and two divergent heterogeneous catalysts, titanium silicalite and silica gel-supported 1,4-bis(9-O-dihydroquinidinyl)phthalazine [SGS-(DHQD)2 PHAL)]-OsO4 complex relays the transport of two electrons from olefin to H2O2 used as a terminal oxidant to provide chiral diols with good yields and high enantiomeric excesses in a single pot.