159857-64-4

Basic information

• Product Name: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide
• Synonyms: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide
• CAS NO: 159857-64-4
• Molecular Weight: 670.852
• Mol File: 159857-64-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide(159857-64-4)
• EPA Substance Registry System: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide(159857-64-4)

Safety Data

• Hazardous Substances Data: 159857-64-4(Hazardous Substances Data)

Usage

General Description

"(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide" is a complex chemical compound with multiple functional groups and a long molecular chain. It contains an amino acid residue, a phenyl group, a methoxy group, and a diphenylmethylamide group. The compound also features a hydroxymethyl-phenyl group attached to the amide. With its multiple functional groups and complex structure, this chemical likely has a diverse range of potential applications in pharmaceuticals, materials science, and other fields.

Upstream product

• 159857-62-2 Fmoc-Phe-Lys(MMT) 
• 159857-61-1 (S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid 
• 450366-22-0 Fmoc-Lys(Mmt)-aminobenzyl alcohol 
• 159857-60-0 Fmoc-Lys(Mmt)-OH 
• 623-04-1 4-aminobenzenemethanol 
• 159857-63-3 Fmoc-Phe-Lys(MMT)-PABOH 

Downstream Products

• 159857-66-6 Carbonic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-phenyl-propionylamino}-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-benzyl ester 4-nitro-phenyl ester 
• 1039044-98-8 O-(2-azidoethyl)-O'-[(N-diglycolyl-2-aminoethyl)-Phe-Lys(MMT)-PAB-OH]heptaethyleneglycol 
• 159857-65-5 MC-Phe-Lys(MMT)-PAB-OH 

Relevant articles and documents

POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO

The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand- targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.

Monomethoxytrityl (MMT) as a versatile amino protecting group for complex prodrugs of anticancer compounds sensitive to strong acids, bases and nucleophiles

Cathepsin B-sensitive maleimidocaproyl-Phe-Lys linker compounds containing acid-sensitive anticancer drugs doxorubicin, mitomycin C and paclitaxel (taxol) attached through a self-immolative p-aminobenzylcarbonyl spacer were prepared using monomethoxytrityl (MMT) as the amino protecting group for Lys. MMT could be removed cleanly and in high yield by dichloroacetic and chloroacetic acids in the presence of anisole with minimal workup.