159857-64-4 Usage
Uses
Used in Pharmaceutical Industry:
(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-[(4-methoxy-phenyl)-diphenyl-methyl]-amino-hexanoic acid (4-hydroxymethyl-phenyl)-amide is used as a pharmaceutical compound for its potential therapeutic properties. The presence of various functional groups allows for interactions with biological targets, making it a candidate for the development of new drugs.
Used in Materials Science:
In the field of materials science, (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-[(4-methoxy-phenyl)-diphenyl-methyl]-amino-hexanoic acid (4-hydroxymethyl-phenyl)-amide is used as a component in the development of advanced materials. Its unique structure and functional groups may contribute to the creation of novel materials with specific properties, such as improved strength, flexibility, or chemical reactivity.
Used in Chemical Research:
(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-[(4-methoxy-phenyl)-diphenyl-methyl]-amino-hexanoic acid (4-hydroxymethyl-phenyl)-amide serves as a valuable compound in chemical research. Its complex structure provides opportunities for studying various chemical reactions and mechanisms, which can lead to a better understanding of organic chemistry and the development of new synthetic methods.
Used in Drug Delivery Systems:
(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-[(4-methoxy-phenyl)-diphenyl-methyl]-amino-hexanoic acid (4-hydroxymethyl-phenyl)-amide may also be utilized in the development of drug delivery systems, where its unique structure and functional groups can be employed to enhance the solubility, stability, or targeted delivery of therapeutic agents. This application could improve the bioavailability and efficacy of existing drugs and facilitate the development of new treatments for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 159857-64-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,8,5 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 159857-64:
(8*1)+(7*5)+(6*9)+(5*8)+(4*5)+(3*7)+(2*6)+(1*4)=194
194 % 10 = 4
So 159857-64-4 is a valid CAS Registry Number.
159857-64-4Relevant academic research and scientific papers
POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO
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Page/Page column 40; 41, (2015/02/25)
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions comprise RGD ligand- targeted amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or conjugate) are further covalently linked to an RNAi trigger.
Synthesis of an immunoconjugate of camptothecin
Walker, Michael A.,Dubowchik, Gene M.,Hofstead, Sandra J.,Trail, Pamela A.,Firestone, Raymond A.
, p. 217 - 219 (2007/10/03)
The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable linker. Endocytosis of the immunoconjugate upon binding to the tumor cell followed by enzymatic cleavage of the linker inside the endosome ensures tumor-specific release of the drug. In this way, it is hoped that the dose-limiting side effects associated with camptothecin can be eliminated while the antitumor activity is preserved.
Monomethoxytrityl (MMT) as a versatile amino protecting group for complex prodrugs of anticancer compounds sensitive to strong acids, bases and nucleophiles
Dubowchik, Gene M.,Radia, Shilpa
, p. 5257 - 5260 (2007/10/03)
Cathepsin B-sensitive maleimidocaproyl-Phe-Lys linker compounds containing acid-sensitive anticancer drugs doxorubicin, mitomycin C and paclitaxel (taxol) attached through a self-immolative p-aminobenzylcarbonyl spacer were prepared using monomethoxytrityl (MMT) as the amino protecting group for Lys. MMT could be removed cleanly and in high yield by dichloroacetic and chloroacetic acids in the presence of anisole with minimal workup.
