159857-65-5

Basic information

• Product Name: MC-Phe-Lys(MMT)-PAB-OH
• Synonyms: MC-Phe-Lys(MMT)-PAB-OH
• CAS NO: 159857-65-5
• Molecular Weight: 864.054
• Mol File: 159857-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: MC-Phe-Lys(MMT)-PAB-OH(CAS DataBase Reference)
• NIST Chemistry Reference: MC-Phe-Lys(MMT)-PAB-OH(159857-65-5)
• EPA Substance Registry System: MC-Phe-Lys(MMT)-PAB-OH(159857-65-5)

Safety Data

• Hazardous Substances Data: 159857-65-5(Hazardous Substances Data)

Upstream product

• 159857-62-2 Fmoc-Phe-Lys(MMT) 
• 450366-22-0 Fmoc-Lys(Mmt)-aminobenzyl alcohol 
• 623-04-1 4-aminobenzenemethanol 
• 55750-63-5 6-maleimidohexanoic acid N-hydroxylsuccinimide ester 
• 159857-64-4 (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide 
• 159857-61-1 (S)-2-amino-6-((4-methoxyphenyl)diphenylmethyl-amino)hexanoic acid 
• 159857-63-3 Fmoc-Phe-Lys(MMT)-PABOH 
• 159857-60-0 Fmoc-Lys(Mmt)-OH 

Downstream Products

• 159857-66-6 Carbonic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-phenyl-propionylamino}-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-benzyl ester 4-nitro-phenyl ester 
• 1083198-41-7 C₈₀H₈₃N₇O₁₅ 

Relevant articles and documents

Synthesis of an immunoconjugate of camptothecin

The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable linker. Endocytosis of the immunoconjugate upon binding to the tumor cell followed by enzymatic cleavage of the linker inside the endosome ensures tumor-specific release of the drug. In this way, it is hoped that the dose-limiting side effects associated with camptothecin can be eliminated while the antitumor activity is preserved.