159858-22-7

Basic information

• Product Name: FMoc-Val-Cit-PAB
• Synonyms: FMoc-Val-Cit-PAB
• CAS NO: 159858-22-7
• Molecular Formula: C₃₃H₃₉N₅O₆
• Molecular Weight: 601.69
• Mol File: 159858-22-7.mol
• Article Data: 25

Chemical Properties

• Melting Point: 204 °C(dec.)
• Boiling Point: 914.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.276±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 10.63±0.46(Predicted)
• CAS DataBase Reference: FMoc-Val-Cit-PAB(CAS DataBase Reference)
• NIST Chemistry Reference: FMoc-Val-Cit-PAB(159858-22-7)
• EPA Substance Registry System: FMoc-Val-Cit-PAB(159858-22-7)

Safety Data

• Hazardous Substances Data: 159858-22-7(Hazardous Substances Data)

Usage

Uses

Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).

Description

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.

Upstream product

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• 159857-81-5 L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- 
• 159857-80-4 N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 
• 159857-79-1 Val-cit-PAB-OH 
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• 159855-98-8 N-[(4-tert-butylphenyl)sulfonyl]alanine 
• 159855-97-7 Glycine,N-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]- 
• 15985-39-4 L-METHIONINE SULFOXIMINE 
• 159853-36-8 4'-O-Methylirenolone 
• 15985-25-8 (5E)-5-(3,4-dimethoxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one 
• 159852-53-6 BIS(HEXAFLUOROISOPROPYL)TEREPHTHALATE 
• 15985-21-4 (5E)-5-(2,5-dimethoxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one 

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• 159860-31-8 4-[(ALPHAR)-ALPHA-((2S,5R)-4-PROPYL-2,5-DEMETHYL-1-PIPERAZINYL)-3-METHOXYBENZYL]-N,N-DIETHYLBENZAMIDE 
• 15986-11-5 1,5-DIHYDRO-6-METHYL-4H-PYRAZOLO[3,4-D]PYRIMIDINE-4-THIONE 
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• 1598-62-5 6-(fluoromethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 15986-25-1 1-{4-[4-(2,4-dichlorophenyl)butyl]phenyl}-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine 
• 15986-26-2 1-[3-chloro-4-(4-phenylbutyl)phenyl]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine 
• 15986-27-3 6,6-dimethyl-1-[4-(4-phenylbutyl)phenyl]-1,6-dihydro-1,3,5-triazine-2,4-diamine 

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