16010-88-1

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 19712-89-1 tert-butyl 2-(4-benzyloxyphenyl)acetate 
• 188119-50-8 diethyl (2-(4-hydroxyphenyl)-2-oxoethyl) phosphate 
• 106-41-2 4-bromo-phenol 
• 51656-70-3 (2-tert-butoxy-2-oxoethyl)zinc(II) bromide 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 6547-53-1 2-[4-(benzyloxy)benzyl]acetic acid 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 7664-93-9 sulfuric acid 
• 1694-31-1 tert-butyl acetoacetate 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 142935-27-1 3,3-diethyl-4-<<4-<<(1,1-dimethylethoxy)carbonyl>methyl>phenyl>oxy>-2-azetidinone 
• 16010-89-2 3-<4-Carboxy-methyl-phenoxy>-4-methoxy-phenylessigsaeure-methylester 
• 147055-86-5 [4-(1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxy)-phenyl]-acetic acid 
• 1027034-44-1 [4-(1-Benzylcarbamoyl-3,3-diethyl-4-oxo-azetidin-2-yloxy)-phenyl]-acetic acid tert-butyl ester 
• 345964-12-7 8,8-dimethyl-5-oxo-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 4-(tert-butoxycarbonylmethyl)phenyl ester 
• 1241507-68-5 C₂₁H₂₅N₃O₃ 
• 1408065-23-5 C₃₆H₅₁N₃O₆ 
• 1408065-24-6 C₃₆H₅₃N₃O₄ 
• 1408065-25-7 C₃₇H₅₂N₄O₄ 
• 1408065-26-8 C₃₃H₄₄N₄O₄ 
• 1408065-22-4 C₁₉H₁₉NO₆ 
• 1620332-75-3 tert-butyl 4-[(10-bromodecyl)oxy]phenylcarbamate 
• 1620332-80-0 tert-butyl 4-[(10-{[4'-(decyloxy)-1,1'-biphenyl-4-yl]oxy}decyl)oxy]phenylcarbamate 
• 1620332-81-1 tert-butyl 4-({10-[(4'-cyano-1,1'-biphenyl-4-yl)oxy]decyl}oxy)phenylcarbamate 

Relevant academic research and scientific papers

Photoinduced Vitamin B12-Catalysis for Deprotection of (Allyloxy)arenes

Vitamin B12 is a natural cobalt complex that, while reduced to the "supernucleophilic" Co(I) form, can easily react with electrophiles via an SN2 mechanism. It is also shown to react via an SN2′ mechanism with allylic compounds allowing for photochemical deprotection of (allyloxy)arenes. A sustainable alternative to commonly used noble metal-catalyzed deprotection reactions is presented.

Palladium-catalyzed α-arylation of zinc enolates of esters: Reaction conditions and substrate scope

The intermolecular α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with i

Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - Development of potential agents for the treatment of Alzheimer's disease

Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP). The Royal Society of Chemis

4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES

Compounds of Formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

Aminoalcohol derivatives

The present invention relates to a compound formula [I]: wherein R1 is hydrogen or halogen, R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, X is bond, —CH2— or —O—, and Y is ?in which R4 is lower alkoxycarbonyl, ?in which R5 is carboxy(lower)alkyl, etc., ?in which R6 is hydroxy, etc., and so on, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS

The present invention relates to a compound formula [I] or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

4-[(8-Ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome P450RAI inhibitory activity

Compounds of Formula 1 1 wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism''s native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism''s native retinoic acid.[From equivalent US6740676] Compounds of Formula 1: STR1wherein the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with retinoids, or which are controlled by or responsive to the organism''s native retinoic acid. Formulations containing the compounds of the invention can also be co-administered with retinoids and/or Vitamin A to enhance or prolong the effects of medications containing retinoids, Vitamin A, or of the organism''s native retinoic acid.

Palladium-catalyzed α-arylation of esters and amides under more neutral conditions

Two procedures for the ∞-arylation of carbonyl compounds under conditions that are more neutral than those of reactions of aryl halides with alkali metal enolates are reported. The first procedure rests upon the development of catalysts bearing the hindered pentaphenylferrocenyl di-tert-butylphosphine (Q-phos) and the highly reactive dimeric Pd(I) complex {P(t-Bu)3]PdBr}2. By this procedure, zinc enolates prepared from ∞-bromo esters and amides react with aryl halides to form ∞-aryl esters and amides in high yields under mild conditions with 1-2 mol % catalyst and with remarkable functional group tolerance. By the second procedure, silyl ketene and silyl ketimine acetals react with aryl bromides in the presence of substoichiometric zinc fluoride, 1 mol % Pd(dba)2, and 2 mol % P(t-Bu)3 in DMF solvent at 80 °C. Reactions of zinc tert-butyl acetate and propionate enolates and trimethylsilyl ketene acetals of tert-butyl propionate and methyl isobutyrate with aryl bromides bearing electron-donating and potentially reactive, base-sensitive electron-withdrawing groups and with pyridyl bromides are reported. In addition, the diastereoselective coupling of phenyl bromide with an imide enolate bearing the Evans auxiliary is reported, and this study shows that racemization of base-sensitive stereocenters does not occur during the coupling process under these more neutral conditions. Copyright

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.