160135-15-9Relevant academic research and scientific papers
Vasopeptidase inhibitors: Incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides
Robl, Jeffrey A.,Sulsky, Richard,Sieber-McMaster, Ellen,Ryono, Denis E.,Cimarusti, Maria P.,Simpkins, Ligaya M.,Karanewsky, Donald S.,Chao, Sam,Asaad, Magdi M.,Seymour, Andrea A.,Fox, Maxine,Smith, Patricia L.,Trippodo, Nick C.
, p. 305 - 311 (2007/10/03)
A series of 7-(di)alkyl and spirocyclic substituted azepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. Clear structure-activity relationships with respect to both angiotensin-converti
SUBSTITUTED AZEPINONE DUAL INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL EXDOPEPTIDASE
-
, (2008/06/13)
Compounds of the formula STR1 are disclosed as possessing inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
