16015-60-4Relevant articles and documents
Microwave synthesis and anticonvulsant activity of 2-benzyl- 1(2H)-phthalazinones
Kornet, Milton J.,Shackleford, George
, p. 1095 - 1096 (1999)
Microwave irradiation of 1(2H)-phthalazinone with benzyl halides and potassium carbonate in dimethylformamide afforded 2- benzyl-1(2H)phthalazinones in modest yields. These products were tested in mice and rats in maximal electroshock and pentylenetetrazo
Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO
Liu, Bin,Zhang, Chunlei,Zhou, Xigeng
, p. 8282 - 8286 (2016/12/02)
The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.
Preparation method of polysubstituted 2-benzyl-1-isoquinolone compound
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Paragraph 0023, (2016/10/09)
The invention discloses a preparation method of a polysubstituted 2-benzyl-1 (2H)-isoquinolone compound. In the presence of an iodine catalyst and tert-butyl hydroperoxide serving as an oxidizing agent, an isoquinoline compound experiences a benzyl free r