16015-60-4

Upstream product

• 119-39-1 phthalazone 
• 201230-82-2 carbon monoxide 
• 19820-56-5 2-formylphenyl tosylate 
• 555-96-4 Benzylhydrazine 
• 90-02-8 salicylaldehyde 
• 253-52-1 PHTHALAZINE 
• 108-88-3 toluene 
• 20570-96-1 benzylhydrazine dihydrochloride 
• 62551-42-2 2-dibromomethyl-benzoic acid 

Relevant academic research and scientific papers

Microwave synthesis and anticonvulsant activity of 2-benzyl- 1(2H)-phthalazinones

Microwave irradiation of 1(2H)-phthalazinone with benzyl halides and potassium carbonate in dimethylformamide afforded 2- benzyl-1(2H)phthalazinones in modest yields. These products were tested in mice and rats in maximal electroshock and pentylenetetrazo

Copper-Mediated Oxidative Functionalization of C(sp3)-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

A copper-mediated oxidative functionalization of C(sp3)-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.

Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO

The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.

Iodine-Catalyzed Oxidative Functionalization of Azaarenes with Benzylic C(sp3)-H Bonds via N-Alkylation/Amidation Cascade: Two-Step Synthesis of Isoindolo[2,1-b]isoquinolin-7(5H)-one

An efficient and practical iodine-catalyzed oxidative functionalization of azaarenes with benzylic C-H bonds via an N-alkylation and amidation cascade is developed to provide isoquinolin-1(2H)-ones. This method utilizes readily available unfunctionalized azaarenes and methylarenes as starting materials and proceeds under metal-free conditions with good to excellent yields, avoiding the use of expensive noble metal catalysts and generation of halide and metal wastes. The synthetic utility of this reaction is exemplified by the concise, two-step synthesis of isoindolo[2,1-b]isoquinolin-7(5H)-one.

Preparation method of polysubstituted 2-benzyl-1-isoquinolone compound

The invention discloses a preparation method of a polysubstituted 2-benzyl-1 (2H)-isoquinolone compound. In the presence of an iodine catalyst and tert-butyl hydroperoxide serving as an oxidizing agent, an isoquinoline compound experiences a benzyl free r

Process for producing phthalazinone and derivatives of the same

1-PHTHALAZINONE AND 1-PHTHALAZINONE DERIVATIVES OF THE FOLLOWING FORMULA: STR1 wherein R1 represents a hydrogen atom, an alkyl group, an aralkyl group, an acyloxyl group, an alkoxyl group, a halogen atom, a nitro group, an amino group or an amido group; and R2 represents a hydrogen atom, an alkyl group or an aryl group. Such can be prepared at good yields by the reaction of a benzoic acid derivative of the following formula: STR2 wherein R1 has the same meanings as defined above; X represents a halogen atom; and Y represents a hydroxyl group, an alkoxyl group or a halogen atom; with hydrazine or a hydrazine derivative of the following formula: wherein R2 has the same meanings as defined above.