160233-76-1

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromoquinoline-4-carboxylic acid is used as a building block for the synthesis of pharmaceuticals and agrochemicals, leveraging its unique chemical structure and functional groups to create novel compounds with therapeutic potential.
Used in Antiviral Applications:
6-Bromoquinoline-4-carboxylic acid is used as an antiviral agent, exhibiting inhibitory effects on viral replication and infection, thereby providing a potential treatment for various viral diseases.
Used in Antibacterial Applications:
6-Bromoquinoline-4-carboxylic acid is used as an antibacterial agent, demonstrating the ability to inhibit bacterial growth and combat infections, contributing to the development of new antimicrobial drugs.
Used in Anticancer Applications:
6-Bromoquinoline-4-carboxylic acid is used as an anticancer agent, showing potential in inhibiting the growth and proliferation of cancer cells, and may be further explored for its role in cancer therapy.
Used in Chemical Industry:
6-Bromoquinoline-4-carboxylic acid is used in the development of fluorescent dyes, taking advantage of its chemical properties to create dyes with specific fluorescence characteristics for various applications, such as bioimaging and diagnostics.
Used as a Reagent in Organic Chemistry:
6-Bromoquinoline-4-carboxylic acid is used as a reagent in organic chemistry, facilitating various chemical reactions and synthesis processes, contributing to the advancement of organic synthesis and the discovery of new compounds.

InChI:InChI=1/C10H6BrNO2/c11-6-1-2-9-8(5-6)7(10(13)14)3-4-12-9/h1-5H,(H,13,14)

Upstream product

• 250641-14-6 6-bromoquinoline-2 ,4-dicarboxylic acid 
• 113-24-6 sodium pyruvate 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 127-17-3 2-oxo-propionic acid 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 4-(6-substituted quinolin-4-yl)-N-aryl thiazol-2-amine derivatives as potential antimicrobial agents

Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide (4a–d) with substituted arylthiourea, (5a–g) afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine (6a-ab). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-negative strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-positive strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Compounds 6a, 6b, 6d, 6f, 6k, and 6l showed moderate to good antibacterial activity against S. albus. Ten derivatives 6c, 6q, 6r, 6s, 6t, 6v, 6w, 6x, 6y, and 6aa, showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole.

Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein

The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic intervention. Surface decoration of metal oxide NPs with ligands modulating circulation time, cellular uptake, affinity and extravasation through active targeting led to efficient cancer specific bioimaging probes. The most relevant cancer biomarkers studied so far include surface and transmembrane cancer cell receptors. More recently, tumor microenvironments and more specifically the fibroblastic element of the tumor stroma have emerged as a valuable target for diagnosis and treatment of several types of cancers. In this study, a low molecular weight ligand targeting fibroblast activation protein α (FAP), which is specifically expressed by activated fibroblasts of the tumor stroma, was synthesized. This ligand demonstrated nanomolar inhibition of FAP with high selectivity with respect to prolyl oligopeptidase (PREP) and dipeptidyl peptidase (DPP) IV, as well as good biocompatibility toward a human lung tissue model. Bismuth ferrite (BFO) harmonic nanoparticles (HNPs) conjugated to this ligand showed target-specific association to FAP as demonstrated by reverse ELISA-type assay using Human Fibroblast Activation Protein alpha/FAP Alexa Fluor 594-conjugated Antibody and multiphoton multispectral microscopy experiments. These functionalized HNPs may provide new nanocarriers to explore the role of FAP in tumorigenesis and to target the fibroblastic component of the tumor microenvironment.

Quinoline formamide compound as well as preparation method and application thereof

The invention discloses quinoline formamide compounds as well as a preparation method and application thereof. Specifically, the invention relates to a compound represented by a formula (I) as shown in the specification or a tautomer, a meso-racemate, a r

Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation

A facile and efficient method for the preparation of 2-non-substituted quinoline-4-carboxylic acids is described via the Pfitzinger reaction of isatins with sodium pyruvate following consequent decarboxylation under microwave irradiation.