250641-14-6

Basic information

• Product Name: 6-BroMoquinoline-2,4-dicarboxylic acid
• Synonyms: 6-BroMoquinoline-2,4-dicarboxylic acid
• CAS NO: 250641-14-6
• Molecular Formula: C₁₁H₆BrNO₄
• Molecular Weight: 296.07364
• Mol File: 250641-14-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 158-160 °C
• Boiling Point: 499.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.873±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.93±0.30(Predicted)
• CAS DataBase Reference: 6-BroMoquinoline-2,4-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMoquinoline-2,4-dicarboxylic acid(250641-14-6)
• EPA Substance Registry System: 6-BroMoquinoline-2,4-dicarboxylic acid(250641-14-6)

Safety Data

• Hazardous Substances Data: 250641-14-6(Hazardous Substances Data)

Usage

General Description

6-Bromoquinoline-2,4-dicarboxylic acid is a chemical compound with the molecular formula C11H6BrNO4. It is a derivative of quinoline and contains two carboxylic acid functional groups. 6-BroMoquinoline-2,4-dicarboxylic acid is often used in organic synthesis and pharmaceutical research due to its potential biological activity and ability to modulate protein-protein interactions. It has been studied for its potential use in drug discovery, particularly in the development of novel anti-cancer or anti-inflammatory agents. Additionally, 6-Bromoquinoline-2,4-dicarboxylic acid has also been investigated for its potential as a building block in the synthesis of various organic compounds.

Upstream product

• 113-24-6 sodium pyruvate 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 106-40-1 4-bromo-aniline 
• 38256-25-6 dimethyl (E)-2-oxoglutaconate 
• 328-50-7 α-ketoglutaric acid 
• 438590-10-4 2,4-dimethyl 6-bromoquinoline-2,4-dicarboxylate 
• 127-17-3 2-oxo-propionic acid 
• 13192-04-6 dimethyl 2-ketoglutarate 

Downstream Products

• 927426-19-5 C₂₃H₄BrF₁₀NO₄ 
• 160233-76-1 6-bromoquinoline-4-carboxylic acid 
• 927426-20-8 C₃₁H₂₄BrF₅N₂O₆ 
• 927426-21-9 C₃₃H₃₃BrN₂O₇ 
• 1532540-17-2 C₁₇H₉Cl₂NO₄ 

Relevant articles and documents

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Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein

The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic intervention. Surface decoration of metal oxide NPs with ligands modulating circulation time, cellular uptake, affinity and extravasation through active targeting led to efficient cancer specific bioimaging probes. The most relevant cancer biomarkers studied so far include surface and transmembrane cancer cell receptors. More recently, tumor microenvironments and more specifically the fibroblastic element of the tumor stroma have emerged as a valuable target for diagnosis and treatment of several types of cancers. In this study, a low molecular weight ligand targeting fibroblast activation protein α (FAP), which is specifically expressed by activated fibroblasts of the tumor stroma, was synthesized. This ligand demonstrated nanomolar inhibition of FAP with high selectivity with respect to prolyl oligopeptidase (PREP) and dipeptidyl peptidase (DPP) IV, as well as good biocompatibility toward a human lung tissue model. Bismuth ferrite (BFO) harmonic nanoparticles (HNPs) conjugated to this ligand showed target-specific association to FAP as demonstrated by reverse ELISA-type assay using Human Fibroblast Activation Protein alpha/FAP Alexa Fluor 594-conjugated Antibody and multiphoton multispectral microscopy experiments. These functionalized HNPs may provide new nanocarriers to explore the role of FAP in tumorigenesis and to target the fibroblastic component of the tumor microenvironment.

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