174674-03-4Relevant academic research and scientific papers
Synthesis and antitumor activity of novel C-7 paclitaxel ethers: Discovery of BMS-184476
Altstadt,Fairchild,Golik,Johnston,Kadow,Lee,Long,Rose,Vyas,Wong,Wu,Wittman
, p. 4577 - 4583 (2001)
The preparation of C-7 paclitaxel ethers is described. Various substituted ethers were prepared via activation of the corresponding methylthiomethyl ether followed by alcohol addition. Variation of the C-7 ether group as well the 3′ side chain position le
Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids
Wittman, Mark D.,Kadow, John F.,Vyas, Dolatrai M.,Lee, Francis L.,Rose, William C.,Long, Byron H.,Fairchild, Craig,Johnston, Kathy
, p. 811 - 814 (2007/10/03)
The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.
