16024-85-4Relevant academic research and scientific papers
A convenient and efficient synthesis of 2-thioxoquinazolinone derivatives via microwave irradiation
Liu, Weiwei,Zhang, Qiang,Gong, Feng,Cao, Zhiling,Huo, Yunfeng
, p. 317 - 321 (2015/03/30)
The synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of isatoic anhydride, primary amine, and carbon disulfide under microwave irradiation. This convenient and efficient method affords the desired products with good to excellent yields. Satisfactory infrared spectroscopy, 1H NMR, and high-resolution mass spectrometry (electrospray ionization) spectra were obtained for all compounds described.
Novel quinazolinone derivatives as possible antitumor agents
El-Sayed Barakat, Saber,Ghorab, Moustafa M.,Saker, Helmy M.,Abd Rabo, Mahmoud M.
, p. 65 - 77 (2007/10/03)
The synthesis of a novel series of quinazolinone derivatives 6-15 having the biologically active thioxo group utilizing 2-isothiocyanato-benzoic acid methyl ester 2 is reported. Their structures have been confirmed on the basis of elemental analyses and (IR, 1H NMR, and mass) spectral data. Preliminary testing for the in vitro antitumor activity of some synthesized compounds against Ehrlich Ascities Carcinoma cells was carried out.
