160247-36-9

Upstream product

• 100-39-0 benzyl bromide 
• 160247-32-5 N-Benzyl-N-((R)-2-hydroxy-1-phenyl-ethyl)-butyramide 
• 14231-57-3 (R)-N-benzyl-2-phenylglycinol 

Downstream Products

• 1017145-79-7 (S)-2-Benzyl-butylamine 
• 198642-58-9 (R)-2-[Benzyl-((S)-2-benzyl-butyl)-amino]-2-phenyl-ethanol 

Relevant academic research and scientific papers

Enantioselective synthesis of β-substituted primary and secondary amines by alkylation of (R)-phenylglycinol amide enolates

General and convenient syntheses of optically active β-substituted secondary or primary amines 4 and 8 are described. The method is based on diastereoselective alkylation of amides 1 and 5 derived from R-(-)-phenylglycinol followed by reduction and removal of the chiral appendage. This procedure has also been applied to the preparation of 1,4-amino alcohols 12 and γ-amino esters 14.

Asymmetric synthesis. XXXIII. Diastereoselective alkylation of N,N-substituted amides

A series of α-substituted amides 3 and 7-9 has been synthesized in enantiomerically pure form by diastereoselective alkylation of N-alkyl phenylglycinol amides 2 and 4-6 respectively. A rigid amide enolate has been postulated to explain the observed diast