198642-58-9

Upstream product

• 160247-36-9 (S)-2,N-Dibenzyl-N-((R)-2-hydroxy-1-phenyl-ethyl)-butyramide 
• 100-39-0 benzyl bromide 
• 160247-32-5 N-Benzyl-N-((R)-2-hydroxy-1-phenyl-ethyl)-butyramide 

Downstream Products

• 1017145-79-7 (S)-2-Benzyl-butylamine 

Relevant academic research and scientific papers

Enantioselective synthesis of β-substituted primary and secondary amines by alkylation of (R)-phenylglycinol amide enolates

General and convenient syntheses of optically active β-substituted secondary or primary amines 4 and 8 are described. The method is based on diastereoselective alkylation of amides 1 and 5 derived from R-(-)-phenylglycinol followed by reduction and removal of the chiral appendage. This procedure has also been applied to the preparation of 1,4-amino alcohols 12 and γ-amino esters 14.