160280-01-3

Basic information

• Product Name: 2,3,4,6-tetra-O-acetyl-1-S-(Z)-4-methoxybenzohydroximoyl-1-thio-β-D-glucopyranose
• Synonyms: 2,3,4,6-tetra-O-acetyl-1-S-(Z)-4-methoxybenzohydroximoyl-1-thio-β-D-glucopyranose
• CAS NO: 160280-01-3
• Molecular Weight: 513.522
• Mol File: 160280-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,3,4,6-tetra-O-acetyl-1-S-(Z)-4-methoxybenzohydroximoyl-1-thio-β-D-glucopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-tetra-O-acetyl-1-S-(Z)-4-methoxybenzohydroximoyl-1-thio-β-D-glucopyranose(160280-01-3)
• EPA Substance Registry System: 2,3,4,6-tetra-O-acetyl-1-S-(Z)-4-methoxybenzohydroximoyl-1-thio-β-D-glucopyranose(160280-01-3)

Safety Data

• Hazardous Substances Data: 160280-01-3(Hazardous Substances Data)

Upstream product

• 3717-21-3 p-methoxyl benzaldoxime 
• 19879-84-6 tetraacetyl thioglucose 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Relevant articles and documents

Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase

Glucopyranosylidene-spiro-1,4,2-oxathiazoles were prepared in high yields by NBS-mediated spiro-cyclization of the corresponding glucosyl-hydroximothioates. In an effort to synthesize analogous glucopyranosylidene-spiro-1,2,4-oxadiazolines, with a nitrogen atom instead of the sulphur, attempted cyclizations resulted in aromatization of the heterocycle with opening of the pyranosyl ring. Enzymatic measurements showed that some of the glucose-based inhibitors were active in the micromolar range. The 2-naphthyl-substituted 1,4,2-oxathiazole displayed the best inhibition against RMGPb (Ki = 160 nM), among glucose-based inhibitors known to date.