160358-07-6

Basic information

• Product Name: 4-amine-1-(3-fluoro)benzylpiperidine
• Synonyms: 4-amine-1-(3-fluoro)benzylpiperidine
• CAS NO: 160358-07-6
• Molecular Weight: 208.279
• Mol File: 160358-07-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-amine-1-(3-fluoro)benzylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amine-1-(3-fluoro)benzylpiperidine(160358-07-6)
• EPA Substance Registry System: 4-amine-1-(3-fluoro)benzylpiperidine(160358-07-6)

Safety Data

• Hazardous Substances Data: 160358-07-6(Hazardous Substances Data)

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 779339-10-5 tert-butyl 1-(3-fluorobenzyl)piperidin-4-ylcarbamate 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 184921-09-3 1-(3-fluoro)benzylpiperidin-4-ol 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 456-42-8 m-fluorobenzyl chloride 
• 380424-08-8 1-(3-fluoro-benzyl)-piperidine-4-carboxylic acid amide 

Downstream Products

• 380426-01-7 2-chloro-6-[4-[1-(3-fluorobenzyl)]piperidinylamino]-9-cyclopentylpurine 

Relevant articles and documents

N-substituted piperidine amide derivative and application thereof

The invention discloses an N-substituted piperidine amide derivative and application thereof and particularly relates to a series of novel N-substituted piperidine amide derivatives and medicine compositions comprising same. The compounds can be used as a

Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties

A novel series of donepezil-trolox hybrids were designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD). Biological assays showed that these derivatives possessed moderate to good inhibitory activities against acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B) as well as remarkable antioxidant effects. The optimal compound 6d exhibited balanced functions with good inhibition against hAChE (IC50 = 0.54 μM) and hMAO-B (IC50 = 4.3 μM), significant antioxidant activity (41.33 μM IC50 by DPPH method, 1.72 and 1.79 trolox equivalent by ABTS and ORAC methods), excellent copper chelation, and Aβ1-42 aggregation inhibition effect. Furthermore, cellular tests indicated that 6d has very low toxicity and is capable of combating oxidative toxin (H2O2, rotenone, and oligomycin-A) induced neurotoxicity. Most importantly, oral administration of 6d demonstrated notable improvements on cognition and spatial memory against scopolamine-induced acute memory deficit as well as d-galactose (d-gal) and AlCl3 induced chronic oxidative stress in a mouse model without acute toxicity and hepatotoxicity. In summary, both in vitro and in vivo results suggested that 6d is a valuable candidate for the development of a safe and effective anti-Alzheimer's drug.

Synthesis of novel N-benzyl substituted piperidine amides of 1H-indole-5-carboxylic acid as potential inhibitors of cholinesterases

A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The target compounds (6b-6e) displayed moderate potency to inhibit BuChE. One of the compounds tested, i.e., 1-benzylpiperidine amide of 1H-indole-5-carboxylic acid (6a) was a weak, non-selective inhibitor for both enzymes. The highest inhibitory activity towards BuChE (30.06% [10 μM]) was determined for compound (6c) which is 1-(3-chloro)benzylpiperidine amide of 1H-indole-5-carboxylic acid.