160384-40-7

Usage

Chemical Properties

Beige Solid

Uses

Ziprasidone (Z485000) derivative.

Upstream product

• 15014-17-2 2-nitrophenyl-malonate 
• 160384-37-2 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethenyl)-nitrobenzene 
• 160384-38-3 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene 
• 7149-76-0 2,5-dichloro-4-nitrotoluene 
• 19398-61-9 2,5-dichlorotoluene 
• 160384-45-2 methyl (5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl)-cyanoacetate 
• 160384-39-4 5-Chloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-2-(bis-(methoxycarbonyl)methyl)-nitrobenzene 

Downstream Products

• 122883-93-6 ziprazidone 
• 160384-41-8 methyl 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl acetate 

Relevant academic research and scientific papers

A novel synthesis of the antipsychotic agent ziprasidone

A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.

Processes and intermediates for the preparation of 5-[2-(4-(benzoisothiazol-3-yl)-piperazin-1-yl)ethyl]-6-chloro-1,3-dihydro-indol-2-one

A process for preparing the compound of the formula STR1 which comprises treating a compound of the formula STR2 wherein R2 is hydrogen, CN or CO2 R1 and R1 is hydrogen or (C1 -C6)alkyl with a reducing agent with the proviso that when R2 is CN or CO2 R1 and R1 is (C1 -C6)alkyl the product of the reduction is heated with an acid. Compounds of formula II wherein R2 is CN or CO2 R1 and R1 is (C1 -C6)alkyl or R2 is hydrogen and R1 is (C1 -C6)alkyl or hydrogen. The compound of formula VII R1 is (C1 -C6)alkyl. The compound of formula III. The compound of formula I is useful in the treatment of psychotic disorders.