160384-45-2

Upstream product

• 160384-38-3 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl)-nitrobenzene 
• 105-34-0 methyl 2-cyanoacetate 
• 19398-61-9 2,5-dichlorotoluene 
• 7149-76-0 2,5-dichloro-4-nitrotoluene 
• 160384-37-2 2,5-Dichloro-4-(2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethenyl)-nitrobenzene 

Downstream Products

• 122883-93-6 ziprazidone 
• 160384-41-8 methyl 5-{2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl}-4-chloro-2-nitrophenyl acetate 
• 160384-40-7 5-(2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl)-4-chloro-2-nitrophenyl acetic acid 

Relevant academic research and scientific papers

A novel synthesis of the antipsychotic agent ziprasidone

A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.