2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) Group As a Base-Labile α-Amino Protection for Solid Phase Peptide Synthesis

Article abstract of DOI:10.1016/0040-4039(94)80127-4

Base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc) group is proposed for a temporary α-amino protection in the solid phase peptide synthesis.Nsc-Group is cleaved by organic bases in aprotic solvents under mild conditions similar to that used for Fmoc-group.Several Nα-Nsc amino acids are prepared and used in the solid phase synthesis of the fragment 307-318 of S-protein from bovine eye retina.