
Tetrahedron Letters p. 7821 - 7824 (1994)
Update date:2022-08-02
Topics:
Samukov, Vladimir V.
Sabirov, Aydar N.
Pozdnyakov, Pavel I.
Base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc) group is proposed for a temporary α-amino protection in the solid phase peptide synthesis.Nsc-Group is cleaved by organic bases in aprotic solvents under mild conditions similar to that used for Fmoc-group.Several Nα-Nsc amino acids are prepared and used in the solid phase synthesis of the fragment 307-318 of S-protein from bovine eye retina.
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