699-06-9

Basic information

• Product Name: 4-HYDROXYBENZALDEHYDE OXIME
• Synonyms: 4-HYDROXYBENZALDEHYDE OXIME
• CAS NO: 699-06-9
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• Mol File: 699-06-9.mol
• Article Data: 68

Chemical Properties

• Melting Point: 111-112℃
• Boiling Point: 292.5°C at 760 mmHg
• Flash Point: 130.7°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.000195mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.65±0.26(Predicted)
• CAS DataBase Reference: 4-HYDROXYBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYBENZALDEHYDE OXIME(699-06-9)
• EPA Substance Registry System: 4-HYDROXYBENZALDEHYDE OXIME(699-06-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 699-06-9(Hazardous Substances Data)

Usage

General Description

4-Hydroxybenzaldehyde oxime is a chemical compound with the formula C7H7NO2. It is an organic compound that is used as a chelating agent, specifically in the extraction and separation of metals. It is known for its ability to form stable complexes with various metal ions, making it useful in analytical chemistry and industrial processes such as metal plating and wastewater treatment. It is also used in pharmaceuticals, particularly in the production of certain drugs and in medicinal chemistry research. Additionally, 4-hydroxybenzaldehyde oxime has potential applications in the field of coordination chemistry and catalysis due to its ability to coordinate with metal ions and form stable complexes.

InChI:InChI=1/C7H7NO2/c9-7-3-1-6(2-4-7)5-8-10/h1-5,8,10H

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 6935-44-0 ethyl (E)-2-cyano-3-(4-hydroxyphenyl)-2-propenoate 
• 108-95-2 phenol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 106-44-5 p-cresol 
• 696-60-6 4-aminomethylphenol 
• 616-38-6 carbonic acid dimethyl ester 
• 22755-24-4 sodium salt of nitromethane 

Downstream Products

• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 26879-83-4 4-hydroxy-3-nitro-benzaldehyde-oxime 
• 767-00-0 4-cyanophenol 
• 160427-15-6 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester 
• 696614-94-5 5-cyano-3-(4-hydroxyphenyl)-4,5-dihydroisoxazole 
• 1004-23-5 4-hydroxy-benzylamine hydrochloride 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 
• 161797-99-5 (2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester) 
• 25984-63-8 4-hydroxythiobenzamide 
• 1071788-87-8 ethyl 3-(4-hydroxyphenyl)-5-methylisoxazole-4-carboxylate 

Relevant articles and documents

A catalytic regioselective procedure for the synthesis of aryl oximes in the presence of palladium nanoparticles

The synthesis of aryl oximes from aryl aldehyde derivatives was carried out using hydroxylamine hydrochloride and aluminum oxy hydroxide-supported palladium (Pd/AlO(OH) nanoparticles. The procedure is revealed via the regioselective synthesis of oxime der

Design, synthesis, in vitro and in silico evaluation of new 3-phenyl-4,5-dihydroisoxazole-5-carboxamides active against drug-resistant mycobacterium tuberculosis

A new series of 3-phenyl-4,5-dihydroisoxazole-5-carboxamides were designed, synthesized, and evaluated for their potency against Mtb H37Rv. Designed molecules were synthesized by one-pot cycloaddition reaction in good to excellent yields. Anti-Tubercular evaluation of all synthesized derivatives identified 6k to be highly potent (MIC 1 μg/mL) against Mtb and drug-resistant strains. All potent derivatives were found to be non-toxic when tested against Vero cells. Also, in silico studies were employed to explore the binding patterns of designed compounds to target Mycobacterial membrane protein Large-3. All derivatives exhibited excellent binding patterns with the receptor. The excellent in silico Absorption, Distribution, Metabolism, and Excretion properties and druggability parameters positions these molecules as promising lead candidates for the future development of new drugs to treat drug-resistant Tuberculosis.

Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase

Stereoselective aldoximes, preferably Z form have been obtained from α-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C–C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality.