160466-01-3Relevant academic research and scientific papers
Total synthesis of michellamines A-C, korupensamines A-D, and ancistrobrevine B
Hoye, Thomas R.,Chen, Minzhang,Hoang, Bac,Mi, Liang,Priest, Owen P.
, p. 7184 - 7201 (2007/10/03)
Efficient syntheses of the title compounds have been developed. Several strategies for preparation of each of the naphthalene and tetrahydroisoquinoline (THIQ) portions were developed. Initial attempts to use benzyne plus furan cycloaddition reactions wer
Biomimetic total synthesis of michellamines A-C
Bringmann, Gerhard,Goetz, Roland,Harmsen, Sven,Holenz, Joerg,Walter, Rainer
, p. 2045 - 2058 (2007/10/03)
The biomimetic first total synthesis of michellamines A, B, and C (1a-c), naturally occurring quateraryl alkaloids with high anti-HIV activity, is described. Key precursors are the molecular "halves" of michellamines, the antimalarial naphthylisoquinoline
The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B
Upender,Pollart,Liu,Hobbs,Olsen,Chao,Bowden,Crase,Thomas,Pandey,Lawson,Dawson
, p. 1371 - 1385 (2007/10/03)
Two simplified analogs of the dimeric naphthalenyltetrahydroisoquinoline alkaloid michellamine B [4',4''-didesmethoxy-2',2''-didesmethylmichellamine B and 6,8-dihydroxy-5-(1',1''-dihydroxy-2',2''-binaphthalen-4'-yl)-1R,3R-dim ethyl-1,2,3,4-tetrahydroisoqu
FIRST TOTAL SYNTHESIS OF KORUPENSAMINES A AND B1
Bringmann, Gerhard,Goetz, Roland,Keller, Paul A.,Walter, Rainer,Henschel, Petra,et al.
, p. 503 - 508 (2007/10/02)
The first total synthesis of korupensamines A (1a) and B (1b), highly polar naphthylisoquinoline alkaloids and, simultaneously, 'monomeric building blocks' of the michellamines, is described.Key step is the PdIIcatalyzed intermolecular biaryl coupling of
