183256-19-1

Upstream product

• 160538-95-4 (1R,3R)-(-)-6,8-dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline 
• 100-39-0 benzyl bromide 
• 178949-48-9 (1R,3R)-2-benzyl-6,8-dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 160538-96-5 (1R-trans)-1,2,3,4-tetrahydro-5-iodo-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline 
• 160466-01-3 (1R-trans)-5-bromo-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-(phenylmethyl)isoquinoline 
• 160539-02-6 (1R-trans)-1,2,3,4-tetrahydro-1,3-dimethyl-6,8-bis(phenylmethoxy)-2-phenylmethylisoquinoline 

Relevant academic research and scientific papers

Total syntheses of korupensamine C and ancistrobrevine B

The first total syntheses of korupensamine C (3) and ancistrobrevine B (4) have been achieved. Important benzyne chemistry related to the construction of the naphthalene moiety, manipulation of methoxy groups on the tetrahydroisoquinoline unit, and hinder

Biomimetic total synthesis of michellamines A-C

The biomimetic first total synthesis of michellamines A, B, and C (1a-c), naturally occurring quateraryl alkaloids with high anti-HIV activity, is described. Key precursors are the molecular "halves" of michellamines, the antimalarial naphthylisoquinoline

The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B

Two simplified analogs of the dimeric naphthalenyltetrahydroisoquinoline alkaloid michellamine B [4',4''-didesmethoxy-2',2''-didesmethylmichellamine B and 6,8-dihydroxy-5-(1',1''-dihydroxy-2',2''-binaphthalen-4'-yl)-1R,3R-dim ethyl-1,2,3,4-tetrahydroisoqu